Gene: WFDC3

140686
WAP14|dJ447F3.3
WAP four-disulfide core domain 3
protein-coding
20q13.12
Ensembl:ENSG00000124116 Vega:OTTHUMG00000032614 UniprotKB:Q8IUB2
NC_000020.11
SNP Mapped
0   ANCO-SNPs
AD
0   
8.689e-1 (AD)  8.837e-1 (ND)   (Frontal_Cortex)
8.562e-1 (AD)  8.754e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IQCD0.435
RABGEF10.431
ABHD10.43
S100A10.41
FXYD10.401
FGGY0.4
SLC48A10.398
HHLA30.394
HDAC110.392
RIBC10.389

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2R1-0.314
BMP5-0.284
PDE6A-0.277
TDRD1-0.277
IGSF10-0.274
MYOCD-0.274
DKK2-0.272
PLA2G4A-0.267
SLC26A7-0.264
PHLDB2-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of WFDC3 mRNA"21346803
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of WFDC3 mRNA"21346803
D020106AcrylamideAcrylamide results in decreased expression of WFDC3 mRNA28959563
C006780bisphenol Abisphenol A results in decreased expression of WFDC3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of WFDC3 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of WFDC3 mRNA27339419
D002737ChloropreneChloroprene results in increased expression of WFDC3 mRNA23125180
D003561CytarabineCytarabine results in decreased expression of WFDC3 mRNA21198554
D004237DiuronDiuron results in increased expression of WFDC3 mRNA25152437
C118739entinostatentinostat results in increased expression of WFDC3 mRNA27188386
D018120FinasterideFinasteride results in increased expression of WFDC3 mRNA24136188
C028473N-acetyl-4-benzoquinoneimineWFDC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WFDC3 mRNA"27106021
C558013NSC 689534NSC 689534 results in increased expression of WFDC3 mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of WFDC3 mRNA26516004
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WFDC3 mRNA19710929
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WFDC3 mRNA21215274
C009495titanium dioxidetitanium dioxide results in decreased expression of WFDC3 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased methylation of WFDC3 gene27618143
D014303TrinitrotolueneTrinitrotoluene affects the expression of WFDC3 mRNA21346803
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of WFDC3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal