Gene: CRY1

1407
DSPD|PHLL1
cryptochrome circadian regulator 1
protein-coding
12q23.3
Ensembl:ENSG00000008405 MIM:601933 Vega:OTTHUMG00000170005 UniprotKB:Q16526
NC_000012.12
PubMed
0   ANCO-SNPs
OD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.816e-2 (AD)  4.584e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARFGAP30.849
TMED50.807
RAP1B0.804
HNRNPF0.804
PPIL40.801
RIPK20.801
UGDH0.799
MCMBP0.796
G3BP10.796
RBM70.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.469
OR4F29-0.446
HES5-0.283
CRYBA2-0.227
LYPD8-0.224
OR2M2-0.218
CHST13-0.211
ASB18-0.202
ADRA1D-0.199
SLC25A45-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CRY1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CRY1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of CRY1 mRNA"20406850
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of CRY1 mRNA28522335
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CRY1 mRNA"25380136
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CRY1 mRNA19191707
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of CRY1 mRNA"17020875
D000082AcetaminophenAcetaminophen results in increased expression of CRY1 mRNA22230336|2570463
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CRY1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CRY1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CRY1 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of CRY1 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CRY1 mRNA28522335
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CRY1 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CRY1 mRNA23912714
D001554BenzeneBenzene affects the expression of CRY1 mRNA16188086
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CRY1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CRY1 mRNA21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CRY1 mRNA20504355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CRY1 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of CRY1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of CRY1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CRY1 mRNA24726801
C006780bisphenol Abisphenol A results in increased expression of CRY1 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of CRY1 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CRY1 mRNA15501611
D019256Cadmium ChlorideCadmium Chloride affects the expression of CRY123085516
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CRY1 mRNA20107868
D019256Cadmium ChlorideMelatonin affects the reaction [Cadmium Chloride affects the expression of CRY1]23085516
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CRY1 mRNA17484886|2733941
D002509CephaloridineCephaloridine results in increased expression of CRY1 mRNA18500788
D002737ChloropreneChloroprene results in increased expression of CRY1 mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CRY1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CRY1 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of CRY1 mRNA19376846
D003042CocaineCocaine results in decreased expression of CRY1 mRNA15994025
D019327Copper SulfateCopper Sulfate results in increased expression of CRY1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CRY1 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of CRY1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of CRY1 mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of CRY1 mRNA21878529
C029892cupric chloridecupric chloride results in decreased expression of CRY1 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of CRY1 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of CRY1 mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of CRY1 mRNA24921660
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CRY1 mRNA27392435
D004008DiclofenacDiclofenac results in decreased expression of CRY1 mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of CRY1 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of CRY1 mRNA23537522
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CRY1 mRNA19031421
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CRY1 mRNA25380136
C062669epicatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY1 mRNA]29061316
C045651epigallocatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY1 mRNA]29061316
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CRY1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRY1 mRNA17942748
D005473FluoxetineFluoxetine affects the expression of CRY1 mRNA15994025
C039281furanfuran results in decreased expression of CRY1 mRNA26194646
D005707Gallic Acid[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY1 mRNA]29061316
C057580gallocatechol[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY1 mRNA]29061316
D006220HaloperidolHaloperidol results in decreased expression of CRY1 mRNA27746588
D006854HydrocortisoneHydrocortisone results in increased expression of CRY1 mRNA21980503
D006861Hydrogen Peroxide[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY1 mRNA]29061316
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CRY1 mRNA29061316
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CRY1 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CRY1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CRY1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CRY1 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CRY1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CRY1 mRNA27339419
C025340manganese chloridemanganese chloride results in decreased expression of CRY1 mRNA28511934
D008550MelatoninMelatonin affects the reaction [Cadmium Chloride affects the expression of CRY1]23085516
D008550MelatoninMelatonin affects the reaction [Rotenone affects the expression of CRY1 mRNA]25430725
D008694MethamphetamineMethamphetamine results in decreased expression of CRY1 mRNA19149911
D008752Methylene ChlorideMethylene Chloride results in decreased expression of CRY1 mRNA28392392
D016685MitomycinMitomycin results in decreased expression of CRY1 mRNA25270620
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of CRY1 mRNA29162477
C051752nefazodonenefazodone results in decreased expression of CRY1 mRNA24136188
D009532NickelNickel results in increased expression of CRY1 mRNA23195993
D000073878Palm OilPalm Oil affects the expression of CRY1 mRNA19680557
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CRY1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CRY1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of CRY1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of CRY1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of CRY1 mRNA11678601
D011239PrednisolonePrednisolone results in decreased expression of CRY1 mRNA16269518
D011374ProgesteroneProgesterone results in decreased expression of CRY1 mRNA23018184
D012402RotenoneMelatonin affects the reaction [Rotenone affects the expression of CRY1 mRNA]25430725
D012402RotenoneRotenone affects the expression of CRY1 mRNA25430725
D012822Silicon DioxideSilicon Dioxide results in increased expression of CRY1 mRNA22431001
D013311StreptozocinStreptozocin results in increased expression of CRY1 mRNA25905778
D013629TamoxifenTamoxifen affects the expression of CRY1 mRNA20937368
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CRY1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CRY1 mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CRY1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CRY1 mRNA21889950|2597527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CRY1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CRY1 mRNA21215274
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CRY1 mRNA19031421
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CRY1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of CRY1 mRNA22378314
C012589trichostatin Atrichostatin A affects the expression of CRY1 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CRY1 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of CRY1 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of CRY1 mRNA22378314
D014520UrethaneUrethane results in increased expression of CRY1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CRY1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CRY1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CRY1 mRNA22083351|2915479
D014635Valproic AcidValproic Acid results in increased expression of CRY1 mRNA29229235
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CRY1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CRY1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of CRY1 mRNA26682919
C111237vorinostatvorinostat results in increased expression of CRY1 mRNA29229235
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of CRY1 mRNA"24525044

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IEA-  
GO:0003677DNA binding-TAS9801304  
GO:0003690double-stranded DNA binding-IDA9801304  
GO:0003904deoxyribodipyrimidine photo-lyase activityNOTIDA8909283  
GO:0003914DNA (6-4) photolyase activityNOTIDA8909283  
GO:0005515protein binding-IPI9383998  17463251  20852621  21613214  21680841  23133559  
GO:0009882blue light photoreceptor activity-NAS8909283  
GO:0019901protein kinase binding-IEA-  
GO:0019902phosphatase binding-IPI9383998  
GO:0035257nuclear hormone receptor binding-IPI22170608  
GO:0042826histone deacetylase binding-IEA-  
GO:0070888E-box binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12397359  14672706  15147242  
GO:0006094gluconeogenesis-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006975DNA damage induced protein phosphorylation-ISS-  
GO:0009785blue light signaling pathway-NAS8909283  
GO:0018298protein-chromophore linkage-IEA-  
GO:0019915lipid storage-IEA-  
GO:0031397negative regulation of protein ubiquitination-ISS-  
GO:0032868response to insulin-IEA-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0033762response to glucagon-ISS-  
GO:0042593glucose homeostasis-ISS-  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0042754negative regulation of circadian rhythm-ISS-  
GO:0043153entrainment of circadian clock by photoperiod-ISS-  
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA12397359  23133559  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:2000001regulation of DNA damage checkpoint-ISS-  
GO:2000323negative regulation of glucocorticoid receptor signaling pathway-ISS-  
GO:2000850negative regulation of glucocorticoid secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005739mitochondrion-IEA-  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence
R-HSA-400253Circadian ClockIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29144171Circadian gene methylation in rotating-shift nurses: a cross-sectional study. (2018 Jan)Reszka EChronobiol Int
26512752Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV. (2015)Lee KAChronobiol Int
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One
17992597Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction. (2007 Aug)Esquifino AIEndocrine
20560679Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes. (2010 Jun 1)Fonseca FMol Diagn Ther