Gene: UBE2F

140739
NCE2
ubiquitin conjugating enzyme E2 F (putative)
protein-coding
2q37.3
Ensembl:ENSG00000184182 MIM:617700 Vega:OTTHUMG00000133341 UniprotKB:Q969M7
NC_000002.12
SNP Mapped
24   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6431570chr2:238015926 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7594965chr2:238002459 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10166061chr2:237997869 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10469607chr2:237996150 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10203101chr2:237994668 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4663276chr2:237990167 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10048643chr2:237989292 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10048814chr2:237989113 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11692068chr2:237988964 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11692064chr2:237988945 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4663819chr2:237988732 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11690668chr2:237988316 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6755573chr2:237986970 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7422865chr2:237984050 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6726393chr2:237982949 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7572717chr2:237981674 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10187736chr2:237978933 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2121472chr2:237976195 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4461215chr2:237975324 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6754093chr2:237974093 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6711485chr2:237974033 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7567199chr2:237971888 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10929255chr2:237970660 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1446924chr2:237969098 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMA70.909
BUD310.897
RRP360.897
MRPL470.893
UBE2D20.892
ARPC20.891
SRSF90.89
MRPL140.89
GLRX50.89
MRPL330.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.728
OR4F29-0.707
P2RY14-0.325
CXCR1-0.257
CXCR2-0.254
VNN3-0.248
MMP9-0.228
RAET1E-0.227
IL18RAP-0.223
C8orf74-0.222

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of UBE2F mRNA"25575267
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of UBE2F mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of UBE2F mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of UBE2F mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of UBE2F mRNA]28655636
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of UBE2F mRNA"25575267
C0293704-toluidine4-toluidine results in decreased expression of UBE2F mRNA27638505
C015001arsenitearsenite results in decreased methylation of UBE2F promoter23974009
D001280AtrazineAtrazine results in decreased expression of UBE2F mRNA22378314
D004958EstradiolEstradiol results in increased expression of UBE2F mRNA25575267
C006780bisphenol Abisphenol A results in increased expression of UBE2F mRNA25575267
C006780bisphenol Abisphenol A results in increased expression of UBE2F mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UBE2F mRNA20061341
D002220CarbamazepineCarbamazepine affects the expression of UBE2F mRNA25979313
C054133casticincasticin results in decreased expression of UBE2F mRNA28444820
C100187chloropicrinchloropicrin results in decreased expression of UBE2F mRNA26352163
D016572CyclosporineCyclosporine results in increased expression of UBE2F mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UBE2F mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of UBE2F mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of UBE2F mRNA25575267
D004964EstriolEstriol results in increased expression of UBE2F mRNA25575267
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of UBE2F mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UBE2F mRNA24096037
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UBE2F mRNA24096037
D005485FlutamideFlutamide results in increased expression of UBE2F mRNA24136188
D005897GlafenineGlafenine results in increased expression of UBE2F mRNA24136188
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UBE2F mRNA20061341
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UBE2F mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UBE2F mRNA"25554681
C051752nefazodonenefazodone results in increased expression of UBE2F mRNA24136188
C016340o,p'-DDT"o,p'-DDT results in increased expression of UBE2F mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of UBE2F mRNA"24096037
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of UBE2F mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of UBE2F mRNA28655636
D010695PhlorhizinPhlorhizin results in decreased expression of UBE2F mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of UBE2F mRNA18301758
C045950propiconazolepropiconazole results in increased expression of UBE2F mRNA21278054
C031280pyrazolepyrazole results in increased expression of UBE2F mRNA17945193
C010327salinomycinsalinomycin results in decreased expression of UBE2F mRNA19682730
D013629TamoxifenTamoxifen affects the expression of UBE2F mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE2F mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UBE2F mRNA19465110
D014212TretinoinTretinoin results in decreased expression of UBE2F mRNA21934132|2372400
C012589trichostatin Atrichostatin A affects the expression of UBE2F mRNA28542535
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of UBE2F mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of UBE2F mRNA28655636

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19250909  
GO:0005524ATP binding-IEA-  
GO:0019788NEDD8 transferase activity-IBA21873635  
GO:0019788NEDD8 transferase activity-TAS-  
GO:0061631ubiquitin conjugating enzyme activity-IBA21873635  
GO:0061654NEDD8 conjugating enzyme activity-IDA19250909  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0045116protein neddylation-IBA21873635  
GO:0045116protein neddylation-IDA19250909  
GO:0045116protein neddylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal