Gene: ADAMTS14

140766
-
ADAM metallopeptidase with thrombospondin type 1 motif 14
protein-coding
10q22.1
Ensembl:ENSG00000138316 MIM:607506 Vega:OTTHUMG00000018414 UniprotKB:Q8WXS8
NG_042147.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
4.231e-1 (AD)  8.995e-1 (ND)   (Frontal_Cortex)
4.377e-1 (AD)  6.677e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12775317chr10:70702527 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02503850chr10:72432552ADAMTS143.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53TG50.867
SLC45A30.858
TMEM63A0.851
SH3TC20.844
PLEKHH10.841
CREB50.834
CARNS10.834
MYRF0.833
KCNH80.829
SEMA6A0.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALB2-0.42
CUX2-0.373
WTIP-0.365
CNGB1-0.359
NPBWR1-0.346
GPR153-0.344
NR2F2-0.333
NEUROD1-0.324
NDNF-0.313
CERKL-0.312

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADAMTS14 gene27153756
D001151ArsenicArsenic affects the methylation of ADAMTS14 gene25304211
C547126AZM551248AZM551248 results in increased expression of ADAMTS14 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ADAMTS14 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ADAMTS14 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ADAMTS14 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of ADAMTS14 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ADAMTS14 mRNA27858113
C006780bisphenol Abisphenol A results in decreased expression of ADAMTS14 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of ADAMTS14 mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ADAMTS14 mRNA27858113
D004041Dietary FatsDietary Fats results in increased expression of ADAMTS14 mRNA25016146
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ADAMTS14 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADAMTS14 mRNA"25554681
D010936Plant ExtractsPlant Extracts results in decreased expression of ADAMTS14 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ADAMTS14 mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of ADAMTS14 mRNA26079696
D053260SootSoot results in increased expression of ADAMTS14 mRNA26551751
D013629TamoxifenTamoxifen results in increased expression of ADAMTS14 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADAMTS14 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADAMTS14 mRNA27562557
D014635Valproic AcidValproic Acid results in increased methylation of ADAMTS14 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0030199collagen fibril organization-IEA-  
GO:0030574collagen catabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1643685DiseaseTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28231306Effects of ADAMTS14 genetic polymorphism and cigarette smoking on the clinicopathologic development of hepatocellular carcinoma. (2017)Sheu MJPLoS One
27463966ADAMTS14 Gene Polymorphism and Environmental Risk in the Development of Oral Cancer. (2016)Su SCPLoS One