Gene: CRY2

1408
HCRY2|PHLL2
cryptochrome circadian regulator 2
protein-coding
11p11.2
Ensembl:ENSG00000121671 MIM:603732 Vega:OTTHUMG00000153225 UniprotKB:Q49AN0
NC_000011.10
PubMed
0   ANCO-SNPs
CD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.028e-1 (AD)  4.621e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15675740chr11:45874617CRY2Gene body5.765e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDK20.921
USP110.911
VPS110.911
PIGS0.91
TSPYL20.91
CRMP10.909
LRRC410.906
CLUH0.905
ASB60.904
DDB10.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.655
OR4F29-0.605
TFPI2-0.413
SPINK8-0.397
CD48-0.387
SH2D1A-0.387
KLF17-0.386
CTNNA3-0.383
MTRNR2L6-0.38
FMO3-0.38

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CRY2 mRNA"26377693
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CRY2 mRNA"28433925
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CRY2 mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CRY2 mRNA"18648102
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CRY2 mRNA19191707
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of CRY2 mRNA"17020875
D000082AcetaminophenAcetaminophen results in increased expression of CRY2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CRY2 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CRY2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CRY2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of CRY2 mRNA20458559
D001280AtrazineAtrazine results in increased expression of CRY2 mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CRY2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CRY2 mRNA26001963
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CRY2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CRY2 mRNA24726801
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CRY2 mRNA"28433925
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of CRY2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CRY2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CRY2 gene28505145
D019256Cadmium ChlorideCadmium Chloride affects the expression of CRY223085516
D019256Cadmium ChlorideCadmium Chloride affects the expression of CRY2 mRNA21442002
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CRY2 mRNA20107868
D019256Cadmium ChlorideMelatonin affects the reaction [Cadmium Chloride affects the expression of CRY2]23085516
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CRY2 gene20938992
D002994ClofibrateClofibrate results in decreased expression of CRY2 mRNA16081524
C018021cobaltous chloridecobaltous chloride results in decreased expression of CRY2 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in increased expression of CRY2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of CRY2 mRNA24386269
D003042CocaineCocaine results in decreased expression of CRY2 mRNA15994025
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of CRY2 mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of CRY2 mRNA21878529
D016572CyclosporineCyclosporine results in increased expression of CRY2 mRNA25562108
C017160cypermethrincypermethrin results in increased expression of CRY2 mRNA21142847
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CRY2 mRNA28628672
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CRY2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of CRY2 mRNA19467301
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CRY2 mRNA"28433925
C062669epicatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY2 mRNA]29061316
C045651epigallocatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY2 mRNA]29061316
D018120FinasterideFinasteride results in decreased expression of CRY2 mRNA24136188
D005473FluoxetineFluoxetine results in decreased expression of CRY2 mRNA15994025
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CRY2 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of CRY2 mRNA19167457
C408042fullerol C60(OH)24fullerol C60(OH)24 results in decreased expression of CRY2 mRNA21513982
D005707Gallic Acid[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY2 mRNA]29061316
C057580gallocatechol[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY2 mRNA]29061316
D017313FenretinideFenretinide results in decreased expression of CRY2 mRNA28973697
D006861Hydrogen Peroxide[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY2 mRNA]29061316
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CRY2 mRNA29061316
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CRY2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CRY2 mRNA28628672
D007657Ketone BodiesKetone Bodies results in decreased expression of CRY2 mRNA16807920
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CRY2 mRNA"24972896
D008550MelatoninMelatonin affects the expression of CRY2 mRNA21442002
D008550MelatoninMelatonin affects the reaction [Cadmium Chloride affects the expression of CRY2]23085516
D008550MelatoninMelatonin affects the reaction [Rotenone affects the expression of CRY2 mRNA]25430725
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CRY2 gene20938992
D008752Methylene ChlorideMethylene Chloride results in increased expression of CRY2 mRNA28392392
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CRY2 mRNA"26251327
C059539midostaurinmidostaurin results in decreased expression of CRY2 mRNA20980353
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of CRY2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CRY2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CRY2 mRNA"25554681
C025589ochratoxin Aochratoxin A results in increased expression of CRY2 mRNA23358140
C005290oxybenzoneoxybenzone results in decreased expression of CRY2 mRNA22721600
D010416PentachlorophenolPentachlorophenol results in increased expression of CRY2 mRNA24642059
C006253pirinixic acidpirinixic acid results in increased expression of CRY2 mRNA17426115
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CRY2 mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of CRY2 mRNA21278054
D012402RotenoneMelatonin affects the reaction [Rotenone affects the expression of CRY2 mRNA]25430725
D012402RotenoneRotenone affects the expression of CRY2 mRNA25430725
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of CRY2 mRNA19122877
C009250sevofluranesevoflurane affects the expression of CRY2 mRNA15967596
D012822Silicon DioxideSilicon Dioxide results in increased expression of CRY2 mRNA25351596
D012834SilverSilver results in increased expression of CRY2 mRNA27131904
D012999SomanSoman results in increased expression of CRY2 mRNA19281266
D013467SulindacSulindac results in decreased expression of CRY2 mRNA24136188
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of CRY2 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CRY2 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CRY2 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CRY2 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CRY2 mRNA18295293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CRY2 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of CRY2 mRNA28973375
C009495titanium dioxidetitanium dioxide results in decreased expression of CRY2 mRNA21513982
D014212TretinoinTretinoin results in increased expression of CRY2 mRNA23724009
C012589trichostatin Atrichostatin A affects the expression of CRY2 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of CRY2 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of CRY2 mRNA29229235
D014635Valproic AcidValproic Acid results in increased expression of CRY2 mRNA15901671
C025643vinclozolinvinclozolin affects the expression of CRY2 mRNA23034163
C025643vinclozolinvinclozolin results in decreased expression of CRY2 mRNA23034163
C111237vorinostatvorinostat results in increased expression of CRY2 mRNA29229235

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-ISS-  
GO:0003677DNA binding-IDA12627958  
GO:0003684damaged DNA binding-IDA12627958  
GO:0003697single-stranded DNA binding-IDA12627958  
GO:0003904deoxyribodipyrimidine photo-lyase activityNOTIDA8909283  
GO:0003914DNA (6-4) photolyase activityNOTIDA8909283  
GO:0005515protein binding-IPI9383998  16790549  17463251  25416956  
GO:0009882blue light photoreceptor activity-NAS8909283  
GO:0019902phosphatase binding-IPI9383998  
GO:0071949FAD binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12397359  14672706  15147242  
GO:0000719photoreactive repairNOTIDA12627958  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007623circadian rhythm-ISS-  
GO:0009416response to light stimulus-IMP15751956  
GO:0009785blue light signaling pathway-NAS8909283  
GO:0018298protein-chromophore linkage-IEA-  
GO:0032515negative regulation of phosphoprotein phosphatase activity-IDA9383998  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0042593glucose homeostasis-ISS-  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0042754negative regulation of circadian rhythm-ISS-  
GO:0043153entrainment of circadian clock by photoperiod-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA12397359  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:2000118regulation of sodium-dependent phosphate transport-IDA9753616  
GO:2000323negative regulation of glucocorticoid receptor signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA9753616  
GO:0005634nucleus-ISS-  
GO:0005829cytosol-IDA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence
R-HSA-400253Circadian ClockIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29144171Circadian gene methylation in rotating-shift nurses: a cross-sectional study. (2018 Jan)Reszka EChronobiol Int
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One
17992597Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction. (2007 Aug)Esquifino AIEndocrine
21130813Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3beta in reward-related brain areas in rats. (2011 Mar 17)Wei YMBehav Brain Res