Gene: ROMO1

140823
C20orf52|MTGM|MTGMP|bA353C18.2
reactive oxygen species modulator 1
protein-coding
20q11.22
Ensembl:ENSG00000125995 Vega:OTTHUMG00000032360 UniprotKB:P60602
NC_000020.11
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.062e-1 (AD)  4.300e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLR2L0.925
OST40.922
RPL360.919
POLR2J0.918
TAF100.916
RPS150.914
DPM30.913
UQCR110.911
RPS210.909
FAU0.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.721
OR4F29-0.718
ZC3H11B-0.253
RGPD1-0.228
PP2D1-0.228
C1orf146-0.224
ZIM2-0.218
ABCA12-0.214
OR10H5-0.208
SIGLEC6-0.193

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ROMO1 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ROMO1 mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ROMO1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ROMO1 protein]26598702
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ROMO1 mRNA28522335
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ROMO1 protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ROMO1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROMO1 mRNA27195522
C006780bisphenol Abisphenol A affects the expression of ROMO1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROMO1 mRNA28628672
C100187chloropicrinchloropicrin affects the expression of ROMO1 mRNA26352163
D004390ChlorpyrifosChlorpyrifos results in increased expression of ROMO1 mRNA26435000
C018021cobaltous chloridecobaltous chloride results in decreased expression of ROMO1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ROMO1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ROMO1 mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of ROMO1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROMO1 mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of ROMO1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of ROMO1 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ROMO1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ROMO1 mRNA]19850644
D005485FlutamideFlutamide results in increased expression of ROMO1 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of ROMO1 mRNA19167457
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ROMO1 mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROMO1 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of ROMO1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ROMO1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROMO1 mRNA28628672
C410337K 7174K 7174 results in decreased expression of ROMO1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of ROMO1 mRNA24136188
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ROMO1 mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ROMO1 protein23718831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ROMO1 mRNA24680724
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ROMO1 mRNA25613284
C066340tolcaponetolcapone results in decreased expression of ROMO1 mRNA24136188
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ROMO1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ROMO1 mRNA29024780
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ROMO1 mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ROMO1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001302replicative cell aging-IMP18836179  
GO:0008284positive regulation of cell proliferation-IDA18313394  
GO:0030150protein import into mitochondrial matrix-IBA21873635  
GO:0031640killing of cells of other organism-IDA22083756  
GO:0031640killing of cells of other organism-IMP22083756  
GO:0034614cellular response to reactive oxygen species-IMP18836179  
GO:0042742defense response to bacterium-IDA22083756  
GO:0045039protein import into mitochondrial inner membrane-IBA21873635  
GO:0050829defense response to Gram-negative bacterium-IDA22083756  
GO:0050829defense response to Gram-negative bacterium-IMP22083756  
GO:0050830defense response to Gram-positive bacterium-IDA22083756  
GO:0051715cytolysis in other organism-IDA22083756  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IMP22083756  
GO:2000379positive regulation of reactive oxygen species metabolic process-IDA16842742  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA16842742  
GO:0005743mitochondrial inner membrane-IEA-  
GO:0005744mitochondrial inner membrane presequence translocase complex-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24951318Serum reactive oxygen species modulator 1 (Romo1) as a potential diagnostic biomarker for non-small cell lung cancer. (2014 Aug)Lee SHLung Cancer
25468147Reactive oxygen species modulator 1 (Romo1) overexpression is an independent predictor of poor survival in NSCLC patients who undergo surgical resection. (2015 Jan)Lee SHLung Cancer
25374412Association of Romo1 gene genetic polymorphisms with risk of gastric cancer in northwestern Chinese population. (2015 Jul)Wu HPathol Oncol Res
27188201Reactive Oxygen Species Modulator 1 (Romo1) Predicts Poor Outcomes in Advanced Non-small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy. (2017 Jan)Lee SHCancer Res Treat
23867822Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells. (2013 Sep 20)Shin JABiochem Biophys Res Commun