Gene: CRYBA4

1413
CTRCT23|CYRBA4|MCOPCT4
crystallin beta A4
protein-coding
22q12.1
Ensembl:ENSG00000196431 MIM:123631 Vega:OTTHUMG00000150983 UniprotKB:P53673
NG_009825.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.227e-1 (AD)  5.402e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2071862chr22:26625437 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALCA0.799
TMEM950.78
ITK0.75
TMPRSS90.734
LRRC150.72
TMPRSS130.686
DEC10.686
CA60.682
KRT33A0.679
GCM10.677

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.278
SFTPC-0.248
OR2L13-0.242
CHAD-0.242
ZNF540-0.238
MYT1-0.234
BCHE-0.232
GPR85-0.232
GPR17-0.223
ASIC2-0.22

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CRYBA4 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CRYBA4 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CRYBA4 mRNA16483693
C547126AZM551248AZM551248 results in increased expression of CRYBA4 mRNA22323515
C487081belinostatbelinostat results in decreased expression of CRYBA4 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CRYBA4 promoter]19654925
C095105bexarotenebexarotene analog results in decreased expression of CRYBA4 mRNA28689802
C006780bisphenol Abisphenol A affects the expression of CRYBA4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CRYBA4 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of CRYBA4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CRYBA4 mRNA21457566
D002110CaffeineCaffeine results in decreased expression of CRYBA4 mRNA23774253
D002220CarbamazepineCarbamazepine results in decreased expression of CRYBA4 mRNA23774253
C018021cobaltous chloridecobaltous chloride results in decreased expression of CRYBA4 mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of CRYBA4 mRNA27523638
D013759DronabinolDronabinol results in decreased expression of CRYBA4 mRNA16616335
D004041Dietary FatsDietary Fats results in increased expression of CRYBA4 mRNA25016146
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CRYBA4 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CRYBA4 mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of CRYBA4 mRNA20003209
C042720mercuric bromidemercuric bromide results in decreased expression of CRYBA4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CRYBA4 mRNA28001369
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CRYBA4 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of CRYBA4 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CRYBA4 mRNA26272509
C016104sodium bichromatesodium bichromate results in increased expression of CRYBA4 mRNA12325037
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CRYBA4 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CRYBA4 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of CRYBA4 mRNA28892372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CRYBA4 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CRYBA4 mRNA23774253
C012589trichostatin Atrichostatin A results in decreased expression of CRYBA4 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of CRYBA4 mRNA23774253
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CRYBA4 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CRYBA4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CRYBA4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CRYBA4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of CRYBA4 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005212structural constituent of eye lens-IEA-  
GO:0005515protein binding-IPI25416956  25910212  
GO ID GO Term Qualifier Evidence PubMed
GO:0007601visual perception-IMP16960806  
GO:0007601visual perception-NAS8999933  
GO:0043010camera-type eye development-IMP16960806  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal