Gene: PARP4

143
ADPRTL1|ARTD4|PARP-4|PARPL|PH5P|VAULT3|VPARP|VWA5C|p193
poly(ADP-ribose) polymerase family member 4
protein-coding
13q12.12
Ensembl:ENSG00000102699 MIM:607519 Vega:OTTHUMG00000016582 UniprotKB:Q9UKK3
NC_000013.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.987e-1 (AD)  9.762e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IRAK40.884
REST0.883
ELF10.877
SFT2D20.875
TP53INP10.869
BNIP20.868
FAM114A10.867
MAGT10.867
STK30.866
CARD80.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRA1D-0.595
HAS1-0.59
MARCH4-0.583
ABCC12-0.57
FBLN7-0.558
GSG1-0.556
SPEF1-0.555
KCNG1-0.554
KCNK3-0.553
SLC7A4-0.551

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PARP4 mRNA"21394737
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PARP4 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PARP4 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PARP4 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of PARP4 mRNA"23195993
D001151ArsenicArsenic results in decreased expression of PARP4 mRNA19654921
C015001arsenitearsenite results in decreased methylation of PARP4 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PARP4 mRNA21839799
D004958EstradiolEstradiol affects the expression of PARP4 mRNA22574217
C584509C646 compoundC646 compound results in increased expression of PARP4 mRNA26191083
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PARP4 mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of PARP4 mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of PARP4 mRNA21878529
C030973cupric oxidecupric oxide results in decreased expression of PARP4 mRNA22077320
D004026DieldrinDieldrin results in decreased expression of PARP4 mRNA28385952
D004317DoxorubicinDoxorubicin results in increased expression of PARP4 mRNA25896364
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PARP4 mRNA22079256
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PARP4 mRNA21179406
C492448ICG 001ICG 001 results in increased expression of PARP4 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PARP4 mRNA25613284
C045463leflunomideleflunomide results in decreased expression of PARP4 mRNA28988120
D008094LithiumLithium results in increased expression of PARP4 mRNA19949822
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PARP4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PARP4 mRNA"25554681
D009532NickelNickel results in decreased expression of PARP4 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of PARP4 mRNA19167457
D009538NicotineNicotine results in increased splicing of PARP4 mRNA alternative form23825647
D010261ParaoxonParaoxon results in increased expression of PARP4 mRNA24413757
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PARP4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PARP4 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of PARP4 protein23718831
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PARP4 mRNA27029645
D014284TriiodothyronineTriiodothyronine results in decreased expression of PARP4 mRNA23397585
C021751tanshinonetanshinone results in increased expression of PARP4 mRNA15849732|1695522
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PARP4 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PARP4 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PARP4 mRNA28065790
D014501UraniumUranium results in increased expression of PARP4 mRNA15672453
C005460uranyl acetateuranyl acetate results in increased expression of PARP4 mRNA15672453
D014635Valproic AcidValproic Acid results in decreased methylation of PARP4 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS10100603  
GO:0003950NAD+ ADP-ribosyltransferase activity-IDA10477748  
GO:0003950NAD+ ADP-ribosyltransferase activity-NAS10644454  
GO:0005515protein binding-IPI15169895  22190034  
GO:0019899enzyme binding-IDA15169895  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-NAS12101391  
GO:0006464cellular protein modification process-IDA10477748  
GO:0006471protein ADP-ribosylation-NAS10644454  
GO:0006954inflammatory response-IMP12123754  
GO:0006974cellular response to DNA damage stimulus-NAS10477748  
GO:0008219cell death-IMP12140175  
GO:0042493response to drug-NAS11291045  
GO:0051972regulation of telomerase activity-IDA15169895  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-NAS10644454  
GO:0005737cytoplasm-IDA10477748  
GO:0005829cytosol-IDA-  
GO:0005876spindle microtubule-IDA10477748  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA19056867  
GO:1990904ribonucleoprotein complex-NAS11479319  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196807Nicotinate metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-197264Nicotinamide salvagingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17203305Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)Figueroa JDHum Genet