Gene: MPP7

143098
-
membrane palmitoylated protein 7
protein-coding
10p12.1
Ensembl:ENSG00000150054 MIM:610973 Vega:OTTHUMG00000017868 UniprotKB:Q5T2T1
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.051e-1 (AD)  9.950e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4749301chr10:28084715 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LZTFL10.926
SLC4A100.92
XK0.918
BHLHB90.916
CNST0.915
GLS0.913
RSPO20.913
CHIC10.912
ADAM220.911
SYNJ10.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.51
HEY2-0.507
S100A1-0.502
LRAT-0.499
COPZ2-0.489
RAB13-0.485
CSAG1-0.484
S100A16-0.481
MYOM1-0.477
MAPKAPK3-0.476

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MPP7 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MPP7 mRNA21632981|2164198
D001151ArsenicArsenic affects the methylation of MPP7 gene25304211
C015001arsenitearsenite results in decreased expression of MPP7 mRNA23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MPP7 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MPP7 mRNA27195522
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MPP7 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of MPP7 mRNA25181051
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MPP7 mRNA]16221973
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of MPP7 mRNA27188386
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MPP7 gene20938992
D003010ClorgylineClorgyline results in increased expression of MPP7 mRNA19691856
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MPP7 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of MPP7 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MPP7 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of MPP7 mRNA23640034
D002117CalcitriolCalcitriol results in increased expression of MPP7 mRNA26485663
D005472FluorouracilFluorouracil results in decreased expression of MPP7 mRNA16510598
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MPP7 gene20938992
D017313FenretinideFenretinide results in decreased expression of MPP7 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MPP7 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MPP7 mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of MPP7 mRNA18927307
D007545IsoproterenolIsoproterenol results in increased expression of MPP7 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MPP7 mRNA24796395
C045463leflunomideleflunomide results in increased expression of MPP7 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MPP7 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MPP7 mRNA23179753|2800136
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MPP7 mRNA20971185
C016030pantogabpantogab results in increased expression of MPP7 mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of MPP7 mRNA24642059
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MPP7 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MPP7 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of MPP7 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of MPP7 mRNA18301758|2081375
D010936Plant ExtractsPlant Extracts results in increased expression of MPP7 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MPP7 mRNA22714537
C045950propiconazolepropiconazole results in increased expression of MPP7 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of MPP7 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of MPP7 mRNA21632981
D012402RotenoneRotenone results in decreased expression of MPP7 mRNA19013527
D012906SmokeSmoke results in decreased expression of MPP7 mRNA21095227
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of MPP7 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MPP7 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MPP7 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MPP7 mRNA21724226
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MPP7 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of MPP7 mRNA23411599
D014520UrethaneUrethane results in decreased expression of MPP7 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MPP7 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of MPP7 mRNA17963808
D014638VanadatesVanadates results in decreased expression of MPP7 mRNA22714537
C111237vorinostatvorinostat results in increased expression of MPP7 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17237226  24366813  
GO:0019904protein domain specific binding-IPI17332497  
GO:0032947protein-containing complex scaffold activity-IDA17237226  20702775  
GO:0035591signaling adaptor activity-NAS14719143  
GO:0035591signaling adaptor activity-TAS20702775  
GO:0045296cadherin binding-HDA25468996  
GO:0046982protein heterodimerization activity-IDA17237226  
GO ID GO Term Qualifier Evidence PubMed
GO:0009967positive regulation of signal transduction-IEA-  
GO:0030010establishment of cell polarity-TAS17332497  
GO:0031334positive regulation of protein complex assembly-IDA17237226  
GO:0031334positive regulation of protein complex assembly-TAS14719143  
GO:0070830bicellular tight junction assembly-IDA17332497  
GO:0071896protein localization to adherens junction-IMP17237226  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005912adherens junction-IDA17237226  
GO:0005923bicellular tight junction-IDA17332497  
GO:0030054cell junction-IDA-  
GO:0097025MPP7-DLG1-LIN7 complex-IDA17237226  20702775  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal