Gene: FRMPD2

143162
PDZD5C|PDZK4|PDZK5C
FERM and PDZ domain containing 2
protein-coding
10q11.22
Ensembl:ENSG00000170324 MIM:613323 Vega:OTTHUMG00000018171 UniprotKB:Q68DX3
NC_000010.11
SNP Mapped
1   ANCO-SNPs
ND
0   
7.922e-1 (AD)  3.988e-1 (ND)   (Frontal_Cortex)
8.944e-1 (AD)  8.558e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs169439chr10:48242632 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRA1D0.76
FNDC50.751
FBLN70.743
KCNK30.733
HUNK0.729
OSBP20.725
MARCH40.722
ABCC120.72
RASGRF10.72
PPEF10.717

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.554
S100A8-0.553
HEBP2-0.545
S100A9-0.542
FCGR3B-0.541
SFT2D2-0.534
YES1-0.53
OTOS-0.529
MYL3-0.528
CARD8-0.527

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of FRMPD2 mRNA"28073004
D000082AcetaminophenAcetaminophen results in increased expression of FRMPD2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FRMPD2 gene27153756
D001151ArsenicArsenic affects the methylation of FRMPD2 gene25304211
D003471CuprizoneCuprizone results in increased expression of FRMPD2 mRNA26577399
D002117CalcitriolCalcitriol results in decreased expression of FRMPD2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of FRMPD2 mRNA21592394
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FRMPD2 mRNA24297863
D012969Sodium FluorideSodium Fluoride results in increased expression of FRMPD2 mRNA27862939
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of FRMPD2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FRMPD2 mRNA21592394
D014520UrethaneUrethane results in decreased expression of FRMPD2 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19706687  
GO:00055451-phosphatidylinositol binding-IDA19706687  
GO ID GO Term Qualifier Evidence PubMed
GO:0070830bicellular tight junction assembly-IMP19706687  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005923bicellular tight junction-IDA19706687  
GO:0016323basolateral plasma membrane-IDA19706687  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal