Gene: SYT9

143425
-
synaptotagmin 9
protein-coding
11p15.4
Ensembl:ENSG00000170743 MIM:613528 Vega:OTTHUMG00000165499 UniprotKB:Q86SS6
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.784e-2 (AD)  1.159e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs977749chr11:7363180 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHLPP10.754
FMNL20.727
SPAG90.718
MBOAT20.718
IGSF110.718
PARP10.715
GCLC0.711
PAQR80.711
ARHGAP230.706
GPRC5B0.704

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.461
OR4F29-0.446
C2orf83-0.305
FMO1-0.282
PCK1-0.279
GSDMA-0.277
FCER2-0.276
GPR31-0.275
FAM20A-0.273
PDE6G-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SYT9 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SYT9 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SYT9 gene27153756
D000447AldehydesAldehydes results in increased expression of SYT9 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYT9 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of SYT9 mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of SYT9 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SYT9 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of SYT9 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SYT9 mRNA17484886
C054133casticincasticin results in decreased expression of SYT9 mRNA28444820
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SYT9 mRNA26272509
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SYT9 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYT9 mRNA20938992
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in decreased expression of SYT9 mRNA18355967
D016572CyclosporineCyclosporine results in decreased expression of SYT9 mRNA20106945
D013759DronabinolDronabinol results in decreased expression of SYT9 mRNA21955143
C118739entinostatentinostat results in increased expression of SYT9 mRNA27188386
D000431EthanolEthanol results in increased expression of SYT9 mRNA21955143
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYT9 mRNA20938992
C412815GW 4064GW 4064 results in increased expression of SYT9 mRNA26655953
C042720mercuric bromidemercuric bromide results in decreased expression of SYT9 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
D008694MethamphetamineMethamphetamine results in decreased expression of SYT9 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYT9 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SYT9 mRNA28001369
D009020MorphineMorphine results in decreased expression of SYT9 mRNA21955143
D009538NicotineNicotine results in decreased expression of SYT9 mRNA21955143
C046012pentanalpentanal results in increased expression of SYT9 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT9 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SYT9 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SYT9 mRNA19710929
C005556propionaldehydepropionaldehyde results in increased expression of SYT9 mRNA26079696
D013853ThioacetamideThioacetamide results in increased methylation of SYT9 promoter27914986
D014212TretinoinTretinoin results in increased expression of SYT9 protein26972010
C012589trichostatin Atrichostatin A results in decreased expression of SYT9 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of SYT9 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of SYT9 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SYT9 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IEA-  
GO:0005509calcium ion binding-IBA21873635  
GO:0005544calcium-dependent phospholipid binding-IBA21873635  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IEA-  
GO:0019905syntaxin binding-IBA21873635  
GO:0030276clathrin binding-IBA21873635  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006906vesicle fusion-IBA21873635  
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0017158regulation of calcium ion-dependent exocytosis-IBA21873635  
GO:0045956positive regulation of calcium ion-dependent exocytosis-IEA-  
GO:0048791calcium ion-regulated exocytosis of neurotransmitter-IBA21873635  
GO:0050796regulation of insulin secretion-IEA-  
GO:0061024membrane organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030665clathrin-coated vesicle membrane-TAS-  
GO:0030667secretory granule membrane-IEA-  
GO:0030672synaptic vesicle membrane-IEA-  
GO:0031045dense core granule-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal