Gene: CSF1R

1436
C-FMS|CD115|CSF-1R|CSFR|FIM2|FMS|HDLS|M-CSF-R
colony stimulating factor 1 receptor
protein-coding
5q32
Ensembl:ENSG00000182578 MIM:164770 Vega:OTTHUMG00000130050 UniprotKB:P07333
NG_012303.1
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.426e-1 (AD)  8.665e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C30.937
APBB1IP0.936
LAPTM50.934
ITGAM0.929
SYK0.929
FGD20.925
TYROBP0.921
RGS100.917
NCKAP1L0.915
AIF10.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.332
MAGIX-0.32
TMEM191C-0.314
HES5-0.312
KRTAP5-7-0.307
ZSCAN1-0.301
GPR148-0.297
ATOH7-0.288
ST6GAL2-0.286
KCNIP3-0.278

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00619ImatinibSmall Molecule152459-95-5ApprovedTarget
DB01268SunitinibSmall Molecule557795-19-4Approved|InvestigationalTarget
DB06080ABT-869Small Molecule-InvestigationalTarget
DB071675-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDESmall MoleculeExperimentalTarget
DB072026-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CSF1R mRNA"25380136
C5495694-cyano-N-(2-(1-cyclohexen-1-yl)-4-(1-((dimethylamino)acetyl)-4-piperidinyl)phenyl)-1H-imidazole-2-carboxamide4-cyano-N-(2-(1-cyclohexen-1-yl)-4-(1-((dimethylamino)acetyl)-4-piperidinyl)phenyl)-1H-imidazole-2-carboxamide results in decreased activity of CSF1R protein22039836
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of CSF1R mRNA19191707
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CSF1R mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CSF1R mRNA23626723
C5585299-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one"9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one binds to CSF1R protein"21322566
D020106AcrylamideAcrylamide results in decreased expression of CSF1R mRNA28959563
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CSF1R mRNA"23195993
D000447AldehydesAldehydes results in increased expression of CSF1R mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CSF1R mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CSF1R mRNA24449571
D001372Aza CompoundsAza Compounds results in decreased expression of CSF1R mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of CSF1R mRNA20521778
D001554BenzeneBenzene promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CSF1R mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CSF1R protein21467743
D004958EstradiolEstradiol results in increased expression of CSF1R mRNA19484750
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of CSF1R mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of CSF1R mRNA25594700
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of CSF1R gene28505145
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of CSF1R gene28505145
C006780bisphenol Abisphenol A results in decreased expression of CSF1R mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CSF1R gene28505145
D002065BuspironeBuspirone results in decreased expression of CSF1R mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of CSF1R mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CSF1R protein21136600
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CSF1R mRNA25993096
D000074262Canola OilCanola Oil metabolite results in decreased expression of CSF1R mRNA27363782
D000074262Canola OilStarch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of CSF1R mRNA]27363782
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CSF1R mRNA27339419
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of CSF1R mRNA18636392
D003300CopperCopper deficiency results in increased expression of CSF1R mRNA26033743
D003471CuprizoneCuprizone results in increased expression of CSF1R mRNA27523638
D003474CurcuminCurcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]15129424
D003474CurcuminCurcumin results in increased expression of CSF1R mRNA22714040
D000069439DasatinibDasatinib binds to CSF1R protein20045709
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of CSF1R mRNA]21095227
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of CSF1R mRNA16556975
D003907DexamethasoneDexamethasone results in increased expression of CSF1R protein15679045
D003907DexamethasoneDexamethasone results in increased expression of CSF1R mRNA21041162
D003994BucladesineBucladesine promotes the reaction [Tretinoin results in increased expression of CSF1R mRNA]8445950
D004008DiclofenacDiclofenac results in increased expression of CSF1R mRNA26934552
D004008DiclofenacDiclofenac results in increased secretion of CSF1R protein26934552
D004041Dietary FatsDietary Fats results in decreased expression of CSF1R mRNA18042831
D019422Dietary SucroseDietary Sucrose results in increased expression of CSF1R mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CSF1R mRNA21041162
D002117CalcitriolCalcitriol results in increased expression of CSF1R mRNA12441127
D002117CalcitriolCSF1R promotes the reaction [Calcitriol results in decreased phosphorylation of RB1 protein]9158000
D002117CalcitriolCSF1R results in increased susceptibility to Calcitriol9158000
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CSF1R mRNA25380136
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of CSF1R mRNA8445950
C070609EMD 53998EMD 53998 analog results in decreased expression of CSF1R mRNA24977338
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CSF1R mRNA12072388
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSF1R mRNA17942748
D011345FenofibrateFenofibrate results in decreased expression of CSF1R mRNA16707586
D005485FlutamideFlutamide results in decreased expression of CSF1R mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of CSF1R mRNA19167457
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of CSF1R gene28505145
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of CSF1R gene28505145
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of CSF1R mRNA16556975
C412815GW 4064GW 4064 results in increased expression of CSF1R mRNA26655953
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in increased expression of CSF1R mRNA8445950
D017313FenretinideFenretinide results in decreased expression of CSF1R mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CSF1R mRNA20044591
C031927hydroquinonehydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
C013038hydroxyhydroquinonehydroxyhydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of CSF1R mRNA19242505
D000068877Imatinib MesylateImatinib Mesylate binds to CSF1R protein20045709
D007211IndolesIndoles results in decreased expression of CSF1R mRNA20521778
D007211IndolesIndoles results in increased expression of CSF1R mRNA20521778
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CSF1R mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CSF1R mRNA25961927
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CSF1R mRNA25982114
D048628KetolidesKetolides analog results in increased expression of CSF1R mRNA24967691
C008261lead acetatelead acetate affects the expression of CSF1R mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CSF1R mRNA"11578593
D008070LipopolysaccharidesBenzene promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D008070Lipopolysaccharides[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide7884313
D008070Lipopolysaccharideshydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D008070Lipopolysaccharideshydroxyhydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D008070Lipopolysaccharidesquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D008070LipopolysaccharidesCSF1R affects the reaction [Lipopolysaccharides results in increased expression of ACP5 mRNA]22067001
D008070LipopolysaccharidesCSF1R affects the reaction [Lipopolysaccharides results in increased expression of CTSK mRNA]22067001
D008070LipopolysaccharidesCSF1R affects the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A mRNA]22067001
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CSF1R mRNA22067001
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of CSF1R protein22118570
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of CSF1R protein]22118570
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CSF1R mRNA25613284
C018091maduramicinmaduramicin results in decreased expression of CSF1R mRNA29128925
D008727MethotrexateMethotrexate results in decreased expression of CSF1R mRNA17400583
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CSF1R mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CSF1R mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CSF1R mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CSF1R mRNA25380136
C005274naringinnaringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]21835177
C005274naringinnaringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]21835177
C005274naringinnaringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]21835177
C005274naringinnaringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]21835177
C051752nefazodonenefazodone results in decreased expression of CSF1R mRNA24136188
D009532NickelNickel results in decreased expression of CSF1R mRNA23195993
D009532NickelNickel results in increased expression of CSF1R mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of CSF1R mRNA19167457
C012655nimesulidenimesulide results in decreased expression of CSF1R mRNA24136188
D009569Nitric OxideBenzene promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D009569Nitric Oxide[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide7884313
D009569Nitric Oxidehydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D009569Nitric Oxidehydroxyhydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
D009569Nitric Oxidequinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
C507134ON 01910ON 01910 results in increased expression of CSF1R mRNA22351695
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of CSF1R mRNA24888373
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of CSF1R mRNA18636392
D000073878Palm OilPalm Oil results in decreased expression of CSF1R mRNA18042831
D010269ParaquatParaquat results in increased expression of CSF1R mRNA21371552
D010269ParaquatParaquat affects the expression of CSF1R mRNA15206577
D010269ParaquatParaquat results in increased expression of CSF1R mRNA17077588|1819848
C046012pentanalpentanal results in increased expression of CSF1R mRNA26079696
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CSF1R mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of CSF1R mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of CSF1R mRNA17426115
C006253pirinixic acidpirinixic acid results in decreased expression of CSF1R mRNA16707586
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of CSF1R mRNA24888373
C545373ponatinibponatinib analog results in decreased activity of CSF1R protein21561767
C545373ponatinibponatinib results in decreased activity of CSF1R protein19878872
D017035PravastatinPravastatin results in decreased expression of CSF1R mRNA27225895
D017035PravastatinPravastatin results in decreased expression of CSF1R mRNA27225895
C005556propionaldehydepropionaldehyde results in increased expression of CSF1R mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CSF1R mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CSF1R mRNA27029645
C004532quinonequinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]7884313
C059514resveratrol[resveratrol co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CSF1R mRNA16267019
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of CSF1R protein]22118570
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of CSF1R mRNA25905778
D015474IsotretinoinIsotretinoin results in increased expression of CSF1R mRNA20436886
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CSF1R mRNA23221170
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of CSF1R mRNA]21095227
C017947sodium arsenitesodium arsenite results in increased expression of CSF1R mRNA17879257
C016104sodium bichromatesodium bichromate results in decreased expression of CSF1R mRNA17685462
D012999SomanSoman results in increased expression of CSF1R mRNA19281266
C471405sorafenibsorafenib binds to CSF1R protein20045709
D013213StarchStarch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of CSF1R mRNA]27363782
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of CSF1R mRNA25905778
C473478sunitinibsunitinib binds to CSF1R protein20045709
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of CSF1R mRNA17630414
D013739TestosteroneTestosterone results in decreased expression of CSF1R mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CSF1R mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSF1R mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CSF1R mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CSF1R mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CSF1R mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of CSF1R mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CSF1R mRNA20133372
D024505TocopherolsTocopherols results in increased expression of CSF1R mRNA17056531
D014212TretinoinBucladesine promotes the reaction [Tretinoin results in increased expression of CSF1R mRNA]8445950
D014212TretinoinCSF1R promotes the reaction [Tretinoin results in decreased phosphorylation of RB1 protein]9158000
D014212TretinoinCSF1R results in increased susceptibility to Tretinoin9158000
D014212Tretinoin[LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased expression of PXN protein]16439309
D014212Tretinoin[LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]16439309
D014212Tretinoin[LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]16439309
D014212TretinoinTNF protein promotes the reaction [Tretinoin results in increased expression of CSF1R mRNA]8445950
D014212TretinoinTretinoin results in increased expression of CSF1R mRNA8445950
C057693troglitazonetroglitazone results in increased expression of CSF1R mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of CSF1R mRNA23527032
C025643vinclozolinvinclozolin results in increased expression of CSF1R mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005011macrophage colony-stimulating factor receptor activity-IMP7683918  20504948  
GO:0005011macrophage colony-stimulating factor receptor activity-ISS-  
GO:0005515protein binding-IPI22153499  22483114  22902366  23478061  26235028  
GO:0005524ATP binding-IEA-  
GO:0019838growth factor binding-IBA21873635  
GO:0019903protein phosphatase binding-IEA-  
GO:0019955cytokine binding-IDA20504948  
GO:0019955cytokine binding-ISS19017797  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0042803protein homodimerization activity-ISS19017797  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IMP20504948  
GO:0006954inflammatory response-TAS19132917  
GO:0007165signal transduction-TAS8981357  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-ISS-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007275multicellular organism development-TAS8981357  
GO:0007411axon guidance-IEA-  
GO:0008283cell proliferation-IMP7683918  
GO:0008284positive regulation of cell proliferation-IMP15117969  20504948  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0008360regulation of cell shape-IMP15117969  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IDA20504948  
GO:0019221cytokine-mediated signaling pathway-IMP20504948  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0021772olfactory bulb development-IEA-  
GO:0021879forebrain neuron differentiation-IEA-  
GO:0030097hemopoiesis-IMP7683918  
GO:0030154cell differentiation-IBA21873635  
GO:0030224monocyte differentiation-TAS19132917  
GO:0030225macrophage differentiation-TAS19132917  
GO:0030316osteoclast differentiation-ISS-  
GO:0030335positive regulation of cell migration-ISS-  
GO:0031529ruffle organization-ISS-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0036006cellular response to macrophage colony-stimulating factor stimulus-IBA21873635  
GO:0036006cellular response to macrophage colony-stimulating factor stimulus-IMP7683918  20504948  
GO:0038145macrophage colony-stimulating factor signaling pathway-ISS-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-ISS-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0045087innate immune response-IEA-  
GO:0045124regulation of bone resorption-ISS-  
GO:0045217cell-cell junction maintenance-IMP15117969  
GO:0046488phosphatidylinositol metabolic process-ISS-  
GO:0046777protein autophosphorylation-IDA20504948  
GO:0048015phosphatidylinositol-mediated signaling-ISS-  
GO:0060603mammary gland duct morphogenesis-TAS15117969  
GO:0061098positive regulation of protein tyrosine kinase activity-IMP7681396  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:0071345cellular response to cytokine stimulus-ISS-  
GO:0071902positive regulation of protein serine/threonine kinase activity-ISS-  
GO:0090197positive regulation of chemokine secretion-IMP20829061  
GO:2000147positive regulation of cell motility-IMP15117969  
GO:2000249regulation of actin cytoskeleton reorganization-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS2421165  
GO:0009986cell surface-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0043235receptor complex-IBA21873635  
GO:1990682CSF1-CSF1R complex-IBA21873635  
GO:1990682CSF1-CSF1R complex-ISS19017797  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa04380Osteoclast differentiation
hsa04640Hematopoietic cell lineage
hsa05200Pathways in cancer
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449836Other interleukin signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24451080Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)Szymanowska-Narloch AAdv Med Sci
28449811Effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer. (2017 Apr)Yoo SSCancer Genet
25144241A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. (2014 Nov)Kang HGJ Thorac Oncol
28427424Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal. (2017 Apr 20)Walter TJJ Neuroinflammation