Gene: PIWIL4

143689
HIWI2|MIWI2
piwi like RNA-mediated gene silencing 4
protein-coding
11q21
Ensembl:ENSG00000134627 MIM:610315 Vega:OTTHUMG00000167811 UniprotKB:Q7Z3Z4
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.005e-3 (AD)  6.351e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HMGN10.7
GCFC20.69
ANKRD100.681
ZNF1400.675
S100PBP0.674
THOC10.667
ANKRD13A0.667
KATNBL10.666
DONSON0.664
N4BP2L20.659

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.38
OR4F29-0.36
OR4F16-0.24
FAM25A-0.192
LCN1-0.181
CLIC3-0.179
TDGF1-0.174
RNF223-0.174
AVPR2-0.168
KRT84-0.164

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIWIL4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIWIL4 mRNA"27188386
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PIWIL4 mRNA22129741
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PIWIL4 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of PIWIL4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PIWIL4 mRNA26079696
D002737ChloropreneChloroprene results in increased expression of PIWIL4 mRNA23125180
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PIWIL4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of PIWIL4 mRNA19549813
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PIWIL4 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PIWIL4 mRNA22129741
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of PIWIL4 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PIWIL4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PIWIL4 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PIWIL4 mRNA20971185
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PIWIL4 mRNA25895662
D053260SootSoot results in increased expression of PIWIL4 mRNA22461453
C009495titanium dioxidetitanium dioxide results in increased expression of PIWIL4 mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PIWIL4 mRNA28065790
D014212TretinoinTretinoin results in increased expression of PIWIL4 mRNA23724009
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIWIL4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PIWIL4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PIWIL4 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased methylation of PIWIL4 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PIWIL4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004521endoribonuclease activityNOTISS-  
GO:0034584piRNA binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006417regulation of translation-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-ISS-  
GO:0010529negative regulation of transposition-ISS-  
GO:0030154cell differentiation-IEA-  
GO:0031047gene silencing by RNA-ISS-  
GO:0034587piRNA metabolic process-ISS-  
GO:0043046DNA methylation involved in gamete generation-ISS-  
GO:0051321meiotic cell cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0043186P granule-ISS-  
GO:0071547piP-body-ISS-  
KEGG ID KEGG Term
hsa04320Dorso-ventral axis formation
Reactome ID Reactome Term Evidence
R-HSA-211000Gene Silencing by RNAIEA
R-HSA-5601884PIWI-interacting RNA (piRNA) biogenesisIEA
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23398123Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. (2013 May)Kitagawa NCancer Sci