Gene: CSF3R

1441
CD114|GCSFR|SCN7
colony stimulating factor 3 receptor
protein-coding
1p34.3
Ensembl:ENSG00000119535 MIM:138971 Vega:OTTHUMG00000008010 UniprotKB:Q99062
NG_016270.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.843e-1 (AD)  5.659e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14523574chr1:36948570CSF3R8.200e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO1F0.873
RASGRP40.873
PTPRC0.87
ALOX50.868
CD370.862
CLEC7A0.858
TBXAS10.853
WAS0.851
HLA-DMB0.847
HCLS10.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.481
MARCH4-0.474
KCNG1-0.474
WNT7A-0.465
KCNIP3-0.464
ATOH7-0.46
NEUROD6-0.46
ZNF835-0.458
CHRNA4-0.454
HAS1-0.452

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00019PegfilgrastimBiotechDrug208265-92-3ApprovedTarget
DB00099FilgrastimBiotechDrug121181-53-1ApprovedTarget
DB05249FavIdSmall Molecule-InvestigationalTarget
DB13144LenograstimBiotechDrug135968-09-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CSF3R mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of CSF3R mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of CSF3R mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CSF3R gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CSF3R mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of CSF3R mRNA18585445
D001151ArsenicArsenic results in decreased expression of CSF3R mRNA19654921
D001241AspirinAspirin results in decreased expression of CSF3R mRNA15928584
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of CSF3R mRNA18585445
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CSF3R mRNA22228805
D004958EstradiolEstradiol results in increased expression of CSF3R mRNA12469912
C006780bisphenol Abisphenol A results in increased expression of CSF3R mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of CSF3R mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of CSF3R mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CSF3R gene28505145
D002737ChloropreneChloroprene results in decreased expression of CSF3R mRNA23125180
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CSF3R mRNA26033743
D003300CopperCopper deficiency results in increased expression of CSF3R mRNA26033743
D003436Croton OilCroton Oil results in increased expression of CSF3R mRNA19647056
D016572CyclosporineCyclosporine results in decreased expression of CSF3R mRNA25562108
D002945CisplatinCisplatin results in decreased expression of CSF3R mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of CSF3R mRNA25016146
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CSF3R mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CSF3R mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of CSF3R mRNA26485663
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CSF3R mRNA19647056
D004317DoxorubicinCSF3 protein inhibits the reaction [Doxorubicin results in decreased expression of CSF3R protein]17334414
D004317DoxorubicinDoxorubicin results in decreased expression of CSF3R protein17334414
C039281furanfuran results in decreased expression of CSF3R mRNA25539665
C039281furanfuran results in increased expression of CSF3R mRNA27387713
D017313FenretinideFenretinide results in increased expression of CSF3R mRNA28973697
C027185indirubinindirubin results in increased expression of CSF3R protein16115123
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CSF3R mRNA25961927
C018091maduramicinmaduramicin results in decreased expression of CSF3R mRNA29128925
D008727MethotrexateMethotrexate results in decreased expression of CSF3R mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CSF3R mRNA23103053
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in decreased expression of CSF3R mRNA20020106
D009151Mustard GasMustard Gas results in decreased expression of CSF3R mRNA16173061
D009151Mustard GasMustard Gas results in increased expression of CSF3R mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CSF3R mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CSF3R mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of CSF3R mRNA17382205
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CSF3R mRNA27935865
C018620oleoresinsoleoresins results in decreased expression of CSF3R mRNA20008804
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CSF3R mRNA25729387
D010081OxazoloneOxazolone results in increased expression of CSF3R mRNA19647056
D010126OzoneOzone results in decreased expression of CSF3R mRNA17095637
C006253pirinixic acidpirinixic acid results in decreased expression of CSF3R mRNA20813756
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in decreased expression of CSF3R mRNA20020106
D011794QuercetinQuercetin results in decreased expression of CSF3R mRNA21632981
D012999SomanSoman results in increased expression of CSF3R mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CSF3R mRNA28922406
C009495titanium dioxidetitanium dioxide results in increased expression of CSF3R mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CSF3R mRNA20133372
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of CSF3R mRNA"19647056
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CSF3R mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of CSF3R mRNA"19682533
D014212TretinoinTretinoin results in increased expression of CSF3R mRNA16054129|7579340
D014212TretinoinTretinoin results in increased expression of CSF3R protein12441127
C012589trichostatin Atrichostatin A results in decreased expression of CSF3R mRNA15901671
C030665triphenyltintriphenyltin results in increased expression of CSF3R mRNA12788061
D014635Valproic AcidValproic Acid results in increased expression of CSF3R mRNA23527032
D014635Valproic AcidValproic Acid results in increased methylation of CSF3R gene29154799
D014635Valproic AcidValproic Acid affects the expression of CSF3R mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of CSF3R mRNA15901671
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CSF3R mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004896cytokine receptor activity-IEA-  
GO:0004912interleukin-3 receptor activity-IBA21873635  
GO:0005515protein binding-IPI9864141  17363902  
GO:0019955cytokine binding-IBA21873635  
GO:0019978interleukin-3 binding-IBA21873635  
GO:0038023signaling receptor activity-TAS7542747  
GO:0051916granulocyte colony-stimulating factor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006952defense response-TAS7542747  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-NAS1371413  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030593neutrophil chemotaxis-IEA-  
GO:0045637regulation of myeloid cell differentiation-IEA-  
GO:0097186amelogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7542747  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa05200Pathways in cancer
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449836Other interleukin signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20862590Gene expression analysis in induced sputum from welders with and without airway-related symptoms. (2011 Jan)Jonsson LSInt Arch Occup Environ Health