Gene: PLEKHA7

144100
-
pleckstrin homology domain containing A7
protein-coding
11p15.2-p15.1
Ensembl:ENSG00000166689 MIM:612686 Vega:OTTHUMG00000165954 UniprotKB:Q6IQ23
NC_000011.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.902e-1 (AD)  4.134e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs216495chr11:16812963 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFATC10.881
LRP100.866
CDC14A0.865
TRPS10.864
NHSL10.862
IL17RB0.857
RFX20.855
NOTCH20.854
CHDH0.854
WLS0.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MCHR1-0.446
PPEF1-0.444
ABCC12-0.443
MYOZ3-0.443
CACNA1F-0.44
TYRP1-0.434
DUSP27-0.431
SMIM18-0.427
AGMAT-0.425
PTPRR-0.416

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PLEKHA7 mRNA"26377693
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PLEKHA7 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of PLEKHA7 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLEKHA7 mRNA19770486
D006710HomocysteineHomocysteine results in decreased expression of PLEKHA7 mRNA17326132
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLEKHA7 mRNA20106945|2163298
C006780bisphenol Abisphenol A affects the expression of PLEKHA7 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PLEKHA7 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of PLEKHA7 mRNA25979313
D016572CyclosporineCyclosporine results in decreased expression of PLEKHA7 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of PLEKHA7 mRNA25562108
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PLEKHA7 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PLEKHA7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PLEKHA7 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of PLEKHA7 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of PLEKHA7 mRNA16002434
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLEKHA7 mRNA22079256
C540355fenamidonefenamidone results in increased expression of PLEKHA7 mRNA27029645
D017313FenretinideFenretinide results in increased expression of PLEKHA7 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PLEKHA7 mRNA27392435
C029938nickel sulfatenickel sulfate results in decreased expression of PLEKHA7 mRNA22714537
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of PLEKHA7 mRNA26678675
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLEKHA7 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PLEKHA7 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PLEKHA7 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of PLEKHA7 mRNA21795739
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PLEKHA7 mRNA27029645
D012906SmokeSmoke results in decreased expression of PLEKHA7 mRNA21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLEKHA7 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLEKHA7 mRNA21570461
D014212TretinoinTretinoin results in decreased expression of PLEKHA7 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PLEKHA7 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of PLEKHA7 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of PLEKHA7 gene29154799
D014640VancomycinVancomycin results in increased expression of PLEKHA7 mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of PLEKHA7 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19041755  28877994  
GO:0070097delta-catenin binding-IDA19041755  
GO ID GO Term Qualifier Evidence PubMed
GO:0045218zonula adherens maintenance-IMP19041755  
GO:0090136epithelial cell-cell adhesion-IMP19041755  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005813centrosome-IDA19041755  
GO:0005829cytosol-IDA-  
GO:0005915zonula adherens-IDA19041755  
GO:0030054cell junction-IDA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal