Gene: SLC2A14

144195
GLUT14|SLC2A3P3
solute carrier family 2 member 14
protein-coding
12p13.31
Ensembl:ENSG00000173262 MIM:611039 Vega:OTTHUMG00000168463 UniprotKB:Q8TDB8
NC_000012.12
SNP Mapped
5   ANCO-SNPs
AD
0   
3.509e-1 (AD)  8.404e-1 (ND)   (Frontal_Cortex)
4.597e-1 (AD)  6.651e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10047605chr12:7870680 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11612319chr12:7864329 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1894829chr12:7861445 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7965203chr12:7847740 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11056079chr12:7844294 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP17L30.473
OR51J10.45
XKR60.422
NYAP20.408
C2orf27B0.401
SLX4IP0.399
OR2T120.395
NPPB0.385
LINC003510.385
GAGE12J0.384

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAPN9-0.203
C9orf43-0.188
HBA2-0.188
HIGD1C-0.184
ZNF479-0.184
CMTM5-0.179
HBB-0.177
HRH4-0.176
C4BPB-0.175
COX8C-0.173

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SLC2A14 mRNA"20816883
D000082AcetaminophenAcetaminophen results in decreased expression of SLC2A14 mRNA29067470
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC2A14 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC2A14 mRNA26238291
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SLC2A14 mRNA28628672
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A14 mRNA20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A14 mRNA20847119
D020122tert-Butylhydroperoxiderosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of SLC2A14 mRNA]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SLC2A14 mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A14 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of SLC2A14 mRNA]20847119
D002104CadmiumCadmium results in decreased expression of SLC2A14 mRNA21120746
D003035Cobalt[tungsten carbide binds to Cobalt] which results in increased expression of SLC2A14 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC2A14 mRNA20105288
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SLC2A14 mRNA28628672
D002945CisplatinCisplatin results in increased expression of SLC2A14 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of SLC2A14 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SLC2A14 mRNA21592394
D005472FluorouracilSLC2A14 protein affects the susceptibility to Fluorouracil16217747
C056507gemcitabinegemcitabine results in increased expression of SLC2A14 mRNA17039268
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SLC2A14 mRNA28628672
D007501IronIron deficiency results in increased expression of SLC2A14 mRNA20368581
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SLC2A14 mRNA28628672
C045463leflunomideleflunomide results in increased expression of SLC2A14 mRNA28988120
C452423N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of SLC2A14 mRNA16052530
D010100OxygenOxygen deficiency results in increased expression of SLC2A14 mRNA20042640|2651600
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A14 mRNA20847119
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A14 mRNA20847119
C089730rosiglitazonerosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of SLC2A14 mRNA]20847119
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC2A14 mRNA25895662
D012834SilverSilver results in increased expression of SLC2A14 mRNA26014281
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SLC2A14 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SLC2A14 mRNA21592394
C004648testosterone enanthatetestosterone enanthate affects the expression of SLC2A14 mRNA17440010
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC2A14 mRNA"26179874
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of SLC2A14 mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of SLC2A14 mRNA]20847119
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in increased expression of SLC2A14 mRNA20105288
D014520UrethaneUrethane results in decreased expression of SLC2A14 mRNA28818685
D014638VanadatesVanadates results in increased expression of SLC2A14 mRNA22714537
D014807Vitamin DVitamin D affects the expression of SLC2A14 mRNA20368581
D015215ZidovudineZidovudine results in decreased expression of SLC2A14 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0055056D-glucose transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0030154cell differentiation-IEA-  
GO:1904659glucose transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-189200Cellular hexose transportTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal