Gene: CSH1

1442
CS-1|CSA|CSMT|GHB3|PL|hCS-1|hCS-A
chorionic somatomammotropin hormone 1
protein-coding
17q23.3
Ensembl:ENSG00000136488 MIM:150200 Vega:OTTHUMG00000171947 UniprotKB:P0DML2
NG_028354.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.695e-1 (AD)  8.143e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR5K41
OR5L20.993
OR5T30.993
OR9G10.967
OR4K170.947
OR10Z10.944
KRTAP27-10.909
OR4C120.909
CDY2A0.909
KRTAP6-20.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.306
ADCY2-0.279
FOXRED2-0.276
TMEM221-0.276
FUT9-0.275
MYBPC1-0.273
TM7SF2-0.271
PTPRF-0.264
SORCS2-0.263
GABRG1-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CSH1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of CSH1 mRNA"25670856
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of CSH1 mRNA]21233418
C006632arsenic trioxidearsenic trioxide results in decreased expression of CSH1 mRNA15761015
C014347decitabinedecitabine results in increased expression of CSH1 mRNA19261194
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of CSH1 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of CSH1 mRNA21233418
D000431EthanolEthanol results in decreased expression of CSH1 protein20621659
D004397FonofosFonofos results in increased methylation of CSH1 promoter22847954
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CSH1 mRNA20044591
D010278ParathionParathion results in increased methylation of CSH1 promoter22847954
D011374ProgesteroneCSH1 protein promotes the reaction [Progesterone results in increased expression of STC1 mRNA]16452456
D011374ProgesteroneProgesterone results in decreased expression of CSH1 mRNA19690047
C005556propionaldehydepropionaldehyde results in decreased expression of CSH1 mRNA26079696
C012568terbufosterbufos results in increased methylation of CSH1 promoter22847954
C012589trichostatin Atrichostatin A results in increased expression of CSH1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of CSH1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005131growth hormone receptor binding-IBA21873635  
GO:0005179hormone activity-IBA21873635  
GO:0005179hormone activity-IEA-  
GO:0005515protein binding-IPI25009770  
GO:0008083growth factor activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0070186growth hormone activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0031667response to nutrient levels-IBA21873635  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IBA21873635  
GO:0045927positive regulation of growth-IBA21873635  
GO:0046427positive regulation of JAK-STAT cascade-IBA21873635  
GO:0048513animal organ development-IBA21873635  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IBA21873635  
GO:0060396growth hormone receptor signaling pathway-IBA21873635  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005783endoplasmic reticulum-IDA6930851  
GO:0031904endosome lumen-TAS-  
GO:0031982vesicle-IDA6930851  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1170546Prolactin receptor signalingIEA
R-HSA-1170546Prolactin receptor signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-982772Growth hormone receptor signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18437100Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue. (2008 Aug)Hussain NPediatr Res