Gene: CSH2

1443
CS-2|CSB|GHB1|PL|hCS-B
chorionic somatomammotropin hormone 2
protein-coding
17q23.3
Ensembl:ENSG00000213218 MIM:118820 Vega:OTTHUMG00000172283 UniprotKB:P0DML3
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.739e-1 (AD)  8.370e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAS2R90.447
OR8H20.441
OR6B10.411
PKHD10.411
CLCN10.396
CSF20.394
OR1S20.392
OR14K10.39
ADAMTS200.376
OR4C160.37

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC8-0.224
CATSPER3-0.217
BOLA2B-0.21
ARIH2OS-0.208
NRL-0.194
PRR5-0.187
BTBD17-0.187
NXNL1-0.187
TST-0.187
ACOT6-0.186

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CSH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CSH2 mRNA"27188386
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CSH2 mRNA26314618
D004397FonofosFonofos results in increased methylation of CSH2 promoter22847954
C051890irinotecanirinotecan analog results in decreased expression of CSH2 mRNA18927307
D010278ParathionParathion results in increased methylation of CSH2 promoter22847954
D010936Plant ExtractsPlant Extracts results in decreased expression of CSH2 mRNA23557933
C012568terbufosterbufos results in increased methylation of CSH2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CSH2 mRNA21296121
C012589trichostatin Atrichostatin A results in increased expression of CSH2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CSH2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CSH2 mRNA24383497
D014635Valproic AcidValproic Acid results in increased methylation of CSH2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005131growth hormone receptor binding-IBA21873635  
GO:0005179hormone activity-IBA21873635  
GO:0005179hormone activity-IEA-  
GO:0008083growth factor activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0070186growth hormone activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0031667response to nutrient levels-IBA21873635  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IBA21873635  
GO:0045927positive regulation of growth-IBA21873635  
GO:0046427positive regulation of JAK-STAT cascade-IBA21873635  
GO:0048513animal organ development-IBA21873635  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IBA21873635  
GO:0060396growth hormone receptor signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005783endoplasmic reticulum-IDA6930851  
GO:0031982vesicle-IDA6930851  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18437100Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue. (2008 Aug)Hussain NPediatr Res