Gene: GLIPR1L2

144321
-
GLIPR1 like 2
protein-coding
12q21.2
Ensembl:ENSG00000180481 MIM:610394 Vega:OTTHUMG00000169756 UniprotKB:Q4G1C9
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
4.627e-1 (AD)  9.154e-1 (ND)   (Frontal_Cortex)
5.482e-1 (AD)  6.139e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CMTM50.61
TCFL50.608
LHPP0.599
C22orf460.595
TPPP30.577
PAQR60.573
PLEKHB10.572
GCSH0.572
PDE11A0.571
EPM2A0.57

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKCD-0.399
TNFRSF11A-0.371
EGR3-0.368
LRRK1-0.367
NRROS-0.359
SH3BP1-0.359
HSPB3-0.359
FHL2-0.356
LRMP-0.353
TP53I11-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GLIPR1L2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GLIPR1L2 mRNA21298039
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GLIPR1L2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of GLIPR1L2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GLIPR1L2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GLIPR1L2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GLIPR1L2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GLIPR1L2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GLIPR1L2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GLIPR1L2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GLIPR1L2 mRNA28628672
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of GLIPR1L2 mRNA25270620
C046012pentanalpentanal results in decreased expression of GLIPR1L2 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GLIPR1L2 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in decreased expression of GLIPR1L2 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GLIPR1L2 promoter]19654925
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GLIPR1L2 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased methylation of GLIPR1L2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007339binding of sperm to zona pellucida-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29299071Lung function discordance in monozygotic twins and associated differences in blood DNA methylation. (2017)Bolund ACSClin Epigenetics