Gene: E2F7

144455
-
E2F transcription factor 7
protein-coding
12q21.2
Ensembl:ENSG00000165891 MIM:612046 Vega:OTTHUMG00000169969 UniprotKB:Q96AV8
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.070e-1 (AD)  1.972e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10506725chr12:77055734 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNC0.474
SPO110.457
DAZL0.438
HELB0.436
TEX190.436
CDC25A0.434
LMNB10.429
DCLRE1B0.428
DNMBP0.423
KIF140.423

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRLHR-0.251
GLRA2-0.229
C10orf95-0.222
CRHBP-0.22
SLC32A1-0.219
SPINK2-0.219
ADRA2C-0.216
CORT-0.213
SFTPC-0.21
C20orf144-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of E2F7 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of E2F7 mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F7 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of E2F7 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of E2F7 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of E2F7 mRNA"20638727
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F7 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of E2F7 mRNA"20713471
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F7 mRNA"25510870
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of E2F7 mRNA"20816883
D000082AcetaminophenAcetaminophen affects the expression of E2F7 mRNA20732408
D000082AcetaminophenAcetaminophen results in increased expression of E2F7 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen results in increased expression of E2F7 mRNA20732408
D016604Aflatoxin B1Aflatoxin B1 affects the expression of E2F7 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of E2F7 mRNA21632981|2164198
D000968Antimycin AAntimycin A results in decreased expression of E2F7 mRNA19304788
D001151ArsenicArsenic results in decreased expression of E2F7 mRNA19945496
D001379AzathioprineAzathioprine results in decreased expression of E2F7 mRNA22623647
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of E2F7 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of E2F7 mRNA21802500
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of E2F7 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of E2F7 mRNA20713471
D004958EstradiolEstradiol results in increased activity of E2F7 protein27592001
D004958EstradiolEstradiol results in increased expression of E2F7 mRNA19167446
C006780bisphenol Abisphenol A results in decreased expression of E2F7 mRNA25181051
D002104CadmiumCadmium results in increased expression of E2F7 mRNA21120746
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of E2F7 mRNA17484886
D002737ChloropreneChloroprene results in increased expression of E2F7 mRNA23125180
D003033Coal TarCoal Tar results in increased expression of E2F7 mRNA27858113
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of E2F7 mRNA18078969
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of E2F7 mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of E2F7 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of E2F7 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of E2F7 mRNA19167446
C029892cupric chloridecupric chloride results in decreased expression of E2F7 mRNA24650576
C030973cupric oxidecupric oxide results in decreased expression of E2F7 mRNA22077320
D016572CyclosporineCyclosporine affects the expression of E2F7 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of E2F7 mRNA21632981
D000069439DasatinibDasatinib results in decreased expression of E2F7 mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of E2F7 mRNA21266533
D002945CisplatinCisplatin results in increased expression of E2F7 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of E2F7 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of E2F7 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of E2F7 mRNA21592394
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of E2F7 mRNA26159488
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of E2F7 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of E2F7 mRNA23649840
D006247HarmineHarmine results in increased expression of E2F7 mRNA25751815
D017313FenretinideFenretinide results in increased expression of E2F7 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of E2F7 mRNA25613284
D007854LeadLead affects the expression of E2F7 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of E2F7 mRNA21641980
D008748MethylcholanthreneMethylcholanthrene results in increased expression of E2F7 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of E2F7 mRNA27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of E2F7 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of E2F7 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of E2F7 mRNA24810058
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of E2F7 mRNA19945496
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of E2F7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of E2F7 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of E2F7 mRNA19812364
D009532NickelNickel results in increased expression of E2F7 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of E2F7 mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in increased expression of E2F7 mRNA"18204070
D010100OxygenOxygen deficiency results in decreased expression of E2F7 mRNA26516004
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of E2F7 mRNA25658374
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F7 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of E2F7 mRNA19084549
D010634PhenobarbitalPhenobarbital affects the expression of E2F7 mRNA23091169
C030090phosphoramide mustardphosphoramide mustard results in increased expression of E2F7 protein26708502
C005556propionaldehydepropionaldehyde results in decreased expression of E2F7 mRNA26079696
D011794QuercetinQuercetin results in increased expression of E2F7 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of E2F7 mRNA19167446
D012402RotenoneRotenone results in decreased expression of E2F7 mRNA19304788
D053260SootSoot results in increased expression of E2F7 mRNA22461453|2655175
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of E2F7 mRNA21641980
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of E2F7 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of E2F7 mRNA21592394
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of E2F7 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of E2F7 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of E2F7 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of E2F7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of E2F7 mRNA24058054
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of E2F7 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of E2F7 mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of E2F7 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of E2F7 mRNA20133372
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of E2F7 mRNA"17951470
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of E2F7 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of E2F7 mRNA"26179874
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of E2F7 mRNA18078969
D014520UrethaneUrethane results in increased expression of E2F7 mRNA28818685
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of E2F7 mRNA"24525044

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000987proximal promoter sequence-specific DNA binding-IDA22903062  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IDA22802528  
GO:0003700DNA-binding transcription factor activity-IMP22903062  
GO:0003714transcription corepressor activity-ISS-  
GO:0005515protein binding-IPI18202719  
GO:0042802identical protein binding-IPI15133492  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA22802528  
GO:0001890placenta development-ISS-  
GO:0002040sprouting angiogenesis-IMP22903062  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0008285negative regulation of cell proliferation-IMP22802528  
GO:0030330DNA damage response, signal transduction by p53 class mediator-IDA22802528  
GO:0032466negative regulation of cytokinesis-ISS-  
GO:0032877positive regulation of DNA endoreduplication-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP22903062  
GO:0060707trophoblast giant cell differentiation-ISS-  
GO:0060718chorionic trophoblast cell differentiation-ISS-  
GO:0070365hepatocyte differentiation-ISS-  
GO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle-IDA22802528  
GO:2000134negative regulation of G1/S transition of mitotic cell cycle-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal