Gene: CSK

1445
-
C-terminal Src kinase
protein-coding
15q24.1
Ensembl:ENSG00000103653 MIM:124095 Vega:OTTHUMG00000142814 UniprotKB:P41240
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.431e-1 (AD)  2.839e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27211576chr15:75093165CSK1.630e-8Maternal smoking in pregnancy27040690
cg27211576chr15:75093165CSK1.670e-10Maternal smoking in pregnancy27040690
cg27211576chr15:75093165CSK9.210e-14Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP4C0.867
P4HB0.856
GRAMD1A0.851
BAX0.849
GPX10.848
LMAN20.847
SLC25A390.846
KDELR10.843
TMED90.842
MGAT10.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.781
OR4F29-0.725
OR6C74-0.193
TNFRSF13B-0.155
AMPD1-0.152
XIRP2-0.151
SLC26A5-0.15
MYL1-0.148
MYH2-0.144
RNASE8-0.141

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
DB02010StaurosporineSmall Molecule62996-74-1ExperimentalTarget
DB05075TG-100801Small MoleculeInvestigationalTarget
ID Drug Name Action PubMed
C0514521,2,3,7,8-pentachlorodibenzo-p-dioxin"1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased activity of CSK protein"9707505
C0514521,2,3,7,8-pentachlorodibenzo-p-dioxin"AHR protein promotes the reaction [1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased activity of CSK protein]"9707505
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CSK mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CSK mRNA"21346803
C0009252,7-dichlorodibenzo-4-dioxin"2,7-dichlorodibenzo-4-dioxin results in increased activity of CSK protein"9707505
C0009252,7-dichlorodibenzo-4-dioxin"AHR protein promotes the reaction [2,7-dichlorodibenzo-4-dioxin results in increased activity of CSK protein]"9707505
C4718436-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine results in decreased activity of CSK protein12534346
D000242Cyclic AMPCSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]1699227
D000242Cyclic AMPCSK protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]1699227
D000242Cyclic AMPCSK protein promotes the reaction [Terbutaline results in increased abundance of Cyclic AMP]1699227
D000242Cyclic AMPIsoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]]1699227
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CSK mRNA22100608
C011512alpha-naphthoflavone[alpha-naphthoflavone results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CSK protein]9707505
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CSK mRNA16483693
D016718Arachidonic AcidArachidonic Acid affects the localization of CSK protein18388244
D016718Arachidonic AcidArachidonic Acid results in increased activity of CSK protein18388244
D001280AtrazineAtrazine results in increased expression of CSK mRNA22378314
D001397Azoxymethane[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein18644992
D001397Azoxymethane[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein18644992
C004456beauvericinbeauvericin results in decreased expression of CSK mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CSK mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CSK mRNA22228805
D004958EstradiolEstradiol affects the expression of CSK mRNA23557687
C006780bisphenol Abisphenol A affects the expression of CSK mRNA21786754|2355768
C006780bisphenol Abisphenol A affects the expression of CSK mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CSK mRNA25181051
C471992bosutinibbosutinib results in decreased activity of CSK protein17114238
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CSK mRNA20360939
C470213capsiate[capsiate binds to CSK protein] which results in decreased activity of CSK protein18172315
C470213capsiatecapsiate inhibits the reaction [VEGFA results in increased activity of CSK protein]18172315
D002994ClofibrateClofibrate results in decreased expression of CSK mRNA17585979
D060729Coal AshCoal Ash results in decreased expression of CSK mRNA19000753
D003035CobaltCobalt binds to CSK protein17149882
D003035Cobalt[Hydroxamic Acids analog co-treated with Cobalt] results in decreased activity of CSK protein17149882
C018021cobaltous chloridecobaltous chloride results in decreased expression of CSK mRNA19320972
D003474CurcuminCurcumin results in decreased expression of CSK18462866
D003520CyclophosphamideCyclophosphamide results in decreased expression of CSK mRNA21041162
D000069439DasatinibDasatinib binds to CSK protein18180381
D003907DexamethasoneDexamethasone results in decreased expression of CSK mRNA21041162
C000944dicrotophosdicrotophos results in increased expression of CSK mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of CSK mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CSK mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CSK mRNA20360939
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CSK mRNA21041162
D002117CalcitriolCalcitriol results in increased localization of [VDR protein co-treated with CSK protein]20371703
D002117CalcitriolCalcitriol results in increased phosphorylation of CSK protein20371703
D002117CalcitriolCSK protein promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]20371703
D002117CalcitriolCSK protein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]20371703
D004317DoxorubicinDoxorubicin results in increased expression of CSK mRNA22008532
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased activity of CSK protein"25856345
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CSK protein23301498
D004837EpinephrineCSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]1699227
D004837EpinephrineIsoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]]1699227
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CSK mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CSK mRNA17942748
D005557FormaldehydeFormaldehyde results in decreased expression of CSK mRNA23649840
C001277geldanamycingeldanamycin inhibits the reaction [AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CSK protein]]9707505
C001277geldanamycingeldanamycin results in decreased activity of CSK protein9707505
C001277geldanamycingeldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]9664232
C001277geldanamycingeldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]9664232
C001277geldanamycingeldanamycin results in decreased activity of CSK protein9664232
D005839GentamicinsGentamicins results in increased expression of CSK mRNA22061828
D006877Hydroxamic Acids[Hydroxamic Acids analog co-treated with Cobalt] results in decreased activity of CSK protein17149882
D007213IndomethacinIndomethacin results in increased expression of CSK mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CSK mRNA25613284
D007545IsoproterenolCSK protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]1699227
D007545IsoproterenolIsoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]]1699227
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CSK mRNA23086925
C410337K 7174K 7174 results in decreased expression of CSK mRNA24086573
D048628KetolidesKetolides analog results in increased expression of CSK mRNA24967691
C045463leflunomideleflunomide results in increased expression of CSK mRNA24136188
C502354lithocholic acid acetateCSK protein promotes the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]20371703
C502354lithocholic acid acetatelithocholic acid acetate results in increased phosphorylation of CSK protein20371703
D008713MethimazoleMethimazole results in decreased expression of CSK mRNA17403546
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CSK mRNA23649840
C028007nickel monoxidenickel monoxide results in increased expression of CSK mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of CSK mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CSK protein19954255
C494474perchlorateperchlorate results in decreased expression of CSK mRNA17403546
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of CSK mRNA19854247
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of CSK protein19854247
D010705PhosgenePhosgene affects the expression of CSK mRNA16300373
C545373ponatinibponatinib results in decreased activity of CSK protein19878872
D011192Potassium DichromatePotassium Dichromate results in increased expression of CSK mRNA11678601
D011374ProgesteroneProgesterone results in decreased expression of CSK mRNA18037150
D011441PropylthiouracilPropylthiouracil results in increased expression of CSK mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of CSK mRNA17403546
D011720PyrazolesPyrazoles analog results in decreased activity of CSK protein12534346
D011743PyrimidinesPyrimidines analog results in decreased activity of CSK protein12534346
C515233saracatinibsaracatinib inhibits the reaction [CSK protein results in decreased expression of CYP7A1 mRNA]20371703
C515233saracatinibsaracatinib results in decreased activity of CSK protein20371703
D012643SeleniumSelenium results in increased expression of CSK mRNA19244175
D012999SomanSoman results in increased expression of CSK mRNA19281266
D013467SulindacCSK protein affects the reaction [Sulindac results in increased expression of CDKN1A protein]18644992
D013467Sulindac[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein18644992
D013467Sulindac[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein18644992
D014284TriiodothyronineCSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]]9664232
D013629TamoxifenTamoxifen affects the expression of CSK mRNA17555576
D013726TerbutalineCSK protein promotes the reaction [Terbutaline results in increased abundance of Cyclic AMP]1699227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CSK mRNA21802500|2315218
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CSK protein]9707505
D013749Tetrachlorodibenzodioxin[alpha-naphthoflavone results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CSK protein]9707505
D013749Tetrachlorodibenzodioxingeldanamycin inhibits the reaction [AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CSK protein]]9707505
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]9707505
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and results in increased activity of CSK protein9707505
D013749TetrachlorodibenzodioxinCSK protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]9664232
D013749TetrachlorodibenzodioxinCSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]]9664232
D013749TetrachlorodibenzodioxinCSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of FOS protein]9664232
D013749TetrachlorodibenzodioxinCSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]9664232
D013749TetrachlorodibenzodioxinCSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]9664232
D013749TetrachlorodibenzodioxinCSK protein results in increased susceptibility to Tetrachlorodibenzodioxin9664232
D013749Tetrachlorodibenzodioxingeldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]9664232
D013749Tetrachlorodibenzodioxingeldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]9664232
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]9664232
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CSK mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CSK mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CSK mRNA25613284
C012589trichostatin Atrichostatin A affects the expression of CSK mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CSK mRNA19042947
D014635Valproic AcidValproic Acid results in increased expression of CSK mRNA23179753
D014639VanadiumVanadium results in decreased expression of CSK mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CSK gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CSK mRNA23034163
D015032ZincZinc binds to CSK protein17149882

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI7507203  10026153  10790433  14665621  15743820  16729043  
17911601  18070987  18614016  19167335  21930792  24658140  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-TAS8890164  
GO:0016301kinase activity-TAS-  
GO:0019903protein phosphatase binding-IEA-  
GO:0034236protein kinase A catalytic subunit binding-IPI17911601  
GO:0042802identical protein binding-IPI19888460  
GO:0046872metal ion binding-IEA-  
GO:0070064proline-rich region binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001817regulation of cytokine production-IBA21873635  
GO:0002250adaptive immune response-IEA-  
GO:0006468protein phosphorylation-TAS1945408  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007420brain development-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010989negative regulation of low-density lipoprotein particle clearance-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0031295T cell costimulation-TAS-  
GO:0032715negative regulation of interleukin-6 production-IEA-  
GO:0033673negative regulation of kinase activity-IEA-  
GO:0034332adherens junction organization-IBA21873635  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0042997negative regulation of Golgi to plasma membrane protein transport-IDA20605918  
GO:0043406positive regulation of MAP kinase activity-IEA-  
GO:0045087innate immune response-IBA21873635  
GO:0045779negative regulation of bone resorption-IEA-  
GO:0048709oligodendrocyte differentiation-IEA-  
GO:0050765negative regulation of phagocytosis-IEA-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0060368regulation of Fc receptor mediated stimulatory signaling pathway-IBA21873635  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEA-  
GO:0071375cellular response to peptide hormone stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005737cytoplasm-TAS8890164  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IPI10790433  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IEA-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
GO:0045121membrane raft-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-177929Signaling by EGFRTAS
R-HSA-180292GAB1 signalosomeTAS
R-HSA-202403TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-354192Integrin alphaIIb beta3 signalingTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS
R-HSA-9006921Integrin signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301898[Evaluation of the indication of carbon monoxide in exhaled air]. (2009)Wozniak KPrzegl Lek