Gene: C12orf66

144577
-
chromosome 12 open reading frame 66
protein-coding
12q14.2
Ensembl:ENSG00000174206 MIM:617420 Vega:OTTHUMG00000168763 UniprotKB:Q96MD2
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.407e-1 (AD)  1.314e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12581277chr12:64203547 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXO30.873
CDK170.859
ATE10.856
ATP8A10.854
ZBTB410.854
DCUN1D40.849
PMS10.847
VPS37A0.847
CD470.847
MTMR60.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.474
OR4F29-0.426
MTRNR2L6-0.404
MTRNR2L10-0.398
MTRNR2L9-0.398
KLRB1-0.376
CSAG1-0.372
MTRNR2L8-0.366
MTRNR2L2-0.363
TTLL10-0.357

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C12ORF66 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C12ORF66 mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of C12ORF66 mRNA24449571
C006780bisphenol Abisphenol A results in increased expression of C12ORF66 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of C12ORF66 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of C12ORF66 mRNA26079696
D016572CyclosporineCyclosporine results in increased expression of C12ORF66 mRNA27989131
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of C12ORF66 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of C12ORF66 mRNA20655997
C045463leflunomideleflunomide results in increased expression of C12ORF66 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of C12ORF66 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of C12ORF66 mRNA23649840
C046012pentanalpentanal results in decreased expression of C12ORF66 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C12ORF66 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of C12ORF66 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of C12ORF66 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of C12ORF66 mRNA22714537
C012589trichostatin Atrichostatin A results in increased expression of C12ORF66 mRNA24935251
D014520UrethaneUrethane results in decreased expression of C12ORF66 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of C12ORF66 mRNA23179753|2493525

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0034198cellular response to amino acid starvation-IBA21873635  
GO:0034198cellular response to amino acid starvation-IMP28199306  
GO:0042149cellular response to glucose starvation-IBA21873635  
GO:0042149cellular response to glucose starvation-IMP28199306  
GO:0061462protein localization to lysosome-IBA21873635  
GO:0061462protein localization to lysosome-IMP28199306  
GO:1904262negative regulation of TORC1 signaling-IBA21873635  
GO:1904262negative regulation of TORC1 signaling-IMP28199306  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-IEA-  
GO:0140007KICSTOR complex-IBA21873635  
GO:0140007KICSTOR complex-IDA28199306  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal