Gene: SERPINA12

145264
OL-64
serpin family A member 12
protein-coding
14q32.13
Ensembl:ENSG00000165953 MIM:617471 Vega:OTTHUMG00000171349 UniprotKB:Q8IW75
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.051e-2 (AD)  6.253e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FLG20.782
KRT20.777
CALML50.744
KRT10.725
CASP140.692
KRTDAP0.686
KRT140.67
MB0.668
XIRP20.654
C1orf680.653

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDT1-0.321
TMEM53-0.281
ZNF575-0.278
GGN-0.275
C16orf95-0.26
ZNF835-0.259
RHO-0.253
HDDC3-0.252
ZNRF4-0.248
BOLA1-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SERPINA12 mRNA"21354444
D020106AcrylamideAcrylamide results in decreased expression of SERPINA12 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SERPINA12 mRNA19770486
D000452AldrinAldrin results in increased expression of SERPINA12 mRNA18579281
D000638AmiodaroneAmiodarone results in decreased expression of SERPINA12 mRNA24535564
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SERPINA12 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of SERPINA12 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SERPINA12 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of SERPINA12 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SERPINA12 mRNA27339419
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SERPINA12 mRNA28962523
D004041Dietary FatsDietary Fats affects the expression of SERPINA12 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of SERPINA12 mRNA15238619
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SERPINA12 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SERPINA12 mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SERPINA12 mRNA24535843
D000431EthanolEthanol results in decreased expression of SERPINA12 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SERPINA12 mRNA17555576
D005839GentamicinsGentamicins results in decreased expression of SERPINA12 mRNA22061828
C000625835HFPO2 compoundHFPO2 compound results in decreased expression of SERPINA12 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in decreased expression of SERPINA12 mRNA27553808
C029424hydrazinehydrazine results in decreased expression of SERPINA12 mRNA15282401
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of SERPINA12 mRNA17616710
D000073878Palm OilPalm Oil affects the expression of SERPINA12 mRNA19680557
C016030pantogabpantogab results in decreased expression of SERPINA12 mRNA17379144
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SERPINA12 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of SERPINA12 mRNA19482888|2309116
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SERPINA12 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SERPINA12 mRNA18445702
D012312RitodrineRitodrine results in decreased expression of SERPINA12 mRNA23370008
C017947sodium arsenitesodium arsenite affects the methylation of SERPINA12 gene28589171
C013698tallowtallow affects the expression of SERPINA12 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of SERPINA12 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPINA12 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SERPINA12 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINA12 mRNA16214954|1817288
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SERPINA12 mRNA28973375
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SERPINA12 mRNA25549359
C057693troglitazonetroglitazone results in decreased expression of SERPINA12 mRNA28973697
D014520UrethaneUrethane results in decreased expression of SERPINA12 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of SERPINA12 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of SERPINA12 mRNA24535564
D014635Valproic AcidValproic Acid results in increased expression of SERPINA12 mRNA24489787
D014752Vinyl ChlorideVinyl Chloride results in increased expression of SERPINA12 mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IEA-  
GO:0045721negative regulation of gluconeogenesis-IEA-  
GO:0046628positive regulation of insulin receptor signaling pathway-IEA-  
GO:0051055negative regulation of lipid biosynthetic process-IEA-  
GO:0090181regulation of cholesterol metabolic process-IEA-  
GO:0090207regulation of triglyceride metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26917578Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. (2016 Jun)Jackson VEThorax