Gene: TTC7B

145567
TTC7L1|c14_5685
tetratricopeptide repeat domain 7B
protein-coding
14q32.11
Ensembl:ENSG00000165914 Vega:OTTHUMG00000171047 UniprotKB:Q86TV6
NC_000014.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.638e-1 (AD)  5.068e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8012052chr14:90781133 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEPT30.966
ATXN7L30.966
EPB41L10.958
PACSIN10.954
IQSEC10.952
TNPO20.952
CDK160.951
CBX70.949
TPRG1L0.947
CALM10.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.685
OR4F29-0.645
TFPI2-0.404
SH2D1A-0.382
CSAG1-0.378
CCR2-0.372
IL18RAP-0.368
SGMS2-0.367
S100A12-0.367
KCNJ15-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TTC7B mRNA19933214
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of TTC7B mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC7B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC7B mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TTC7B mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TTC7B mRNA17562736
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TTC7B mRNA22129741
D020106AcrylamideAcrylamide results in decreased expression of TTC7B mRNA28959563
D020106AcrylamideAcrylamide results in increased expression of TTC7B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TTC7B protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TTC7B mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TTC7B mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TTC7B mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TTC7B mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of TTC7B mRNA20458559
D001280AtrazineAtrazine results in decreased expression of TTC7B mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTC7B mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTC7B mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TTC7B mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of TTC7B mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of TTC7B gene22576693
C006780bisphenol Abisphenol A results in decreased expression of TTC7B mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TTC7B mRNA25181051
D003042CocaineCocaine results in decreased expression of TTC7B mRNA17898221
D003367CotinineCotinine affects the methylation of TTC7B gene22851337
D016572CyclosporineCyclosporine results in increased expression of TTC7B mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TTC7B mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TTC7B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TTC7B mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TTC7B mRNA24535843
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TTC7B mRNA22129741
D004237DiuronDiuron results in increased expression of TTC7B mRNA25152437
C024565ethylene dichlorideethylene dichloride results in decreased expression of TTC7B mRNA28189721
D005557FormaldehydeFormaldehyde results in decreased expression of TTC7B mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TTC7B mRNA22634610
D017313FenretinideFenretinide results in decreased expression of TTC7B mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TTC7B mRNA20044591
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TTC7B mRNA22129741
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TTC7B mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TTC7B mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC7B mRNA"27188386
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of TTC7B mRNA23602845
D010634PhenobarbitalPhenobarbital affects the expression of TTC7B mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TTC7B mRNA19710929
C045950propiconazolepropiconazole results in increased expression of TTC7B mRNA21278054
D011794QuercetinQuercetin results in increased expression of TTC7B mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTC7B mRNA19933214|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTC7B mRNA21215274
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TTC7B mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of TTC7B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TTC7B mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23229899  26571211  
GO ID GO Term Qualifier Evidence PubMed
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO:0046854phosphatidylinositol phosphorylation-IDA23229899  26571211  
GO:0072659protein localization to plasma membrane-IBA21873635  
GO:0072659protein localization to plasma membrane-IDA23229899  26571211  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA23229899  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA23229899  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal