Gene: HAPLN3

145864
EXLD1|HsT19883
hyaluronan and proteoglycan link protein 3
protein-coding
15q26.1
Ensembl:ENSG00000140511 Vega:OTTHUMG00000148680 UniprotKB:Q96S86
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
5.445e-2 (AD)  2.197e-2 (ND)   (Frontal_Cortex)
7.020e-1 (AD)  3.614e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APOL10.811
SP1000.801
IL15RA0.8
TAP10.794
TRIM50.79
SP140L0.786
CASP40.782
NLRC50.781
COL4A20.777
IL18BP0.77

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.365
DRD5-0.34
SLC7A4-0.333
TMEM179-0.325
CPLX3-0.317
ISLR2-0.317
B3GALT2-0.311
GABRA5-0.311
C1orf53-0.308
KCNIP3-0.306

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08818Hyaluronic acidSmall Molecule9004-61-9ApprovedTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of HAPLN3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HAPLN3 mRNA23630614
D000447AldehydesAldehydes results in increased expression of HAPLN3 mRNA25014914
C006780bisphenol Abisphenol A results in decreased expression of HAPLN3 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of HAPLN3 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of HAPLN3 mRNA26079696
D000069439DasatinibDasatinib results in increased expression of HAPLN3 mRNA20579391
D003671DEETDEET results in decreased expression of HAPLN3 mRNA27091632
D002945CisplatinCisplatin results in increased expression of HAPLN3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of HAPLN3 mRNA22023808
D004026DieldrinDieldrin results in decreased expression of HAPLN3 mRNA28385952
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HAPLN3 mRNA19371625
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of HAPLN3 mRNA"27840820
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HAPLN3 mRNA22079256
D015025ZearalenoneZearalenone results in decreased expression of HAPLN3 mRNA19371625
D005485FlutamideFlutamide results in decreased expression of HAPLN3 mRNA21126777
D004397FonofosFonofos results in increased methylation of HAPLN3 promoter22847954
C492448ICG 001ICG 001 results in decreased expression of HAPLN3 mRNA26191083
D007213IndomethacinIndomethacin results in decreased expression of HAPLN3 mRNA25972201
C544151jinfukangjinfukang results in decreased expression of HAPLN3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HAPLN3 mRNA23086925
D008627Mercuric ChlorideMercuric Chloride affects the expression of HAPLN3 mRNA20353558
D009532NickelNickel results in increased expression of HAPLN3 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of HAPLN3 mRNA19167457
C016340o,p'-DDT"o,p'-DDT results in decreased expression of HAPLN3 mRNA"19371625
D010278ParathionParathion results in increased methylation of HAPLN3 promoter22847954
C046012pentanalpentanal results in increased expression of HAPLN3 mRNA26079696
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HAPLN3 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HAPLN3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HAPLN3 mRNA22079256
C005556propionaldehydepropionaldehyde results in increased expression of HAPLN3 mRNA26079696
C012568terbufosterbufos results in increased methylation of HAPLN3 promoter22847954
D014212TretinoinTretinoin results in increased expression of HAPLN3 mRNA20488242
D014635Valproic AcidValproic Acid results in increased methylation of HAPLN3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of HAPLN3 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HAPLN3 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of HAPLN3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IBA21873635  
GO:0007155cell adhesion-IEA-  
GO:0007417central nervous system development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23897225Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis. (2013 Nov)Assassi SArthritis Rheum