Gene: NRG4

145957
HRG4
neuregulin 4
protein-coding
15q24.2
Ensembl:ENSG00000169752 MIM:610894 Vega:OTTHUMG00000142917 UniprotKB:Q8WWG1
NC_000015.10
PubMed
0   ANCO-SNPs
ND
3   
2.258e-1 (AD)  6.055e-1 (ND)   (Frontal_Cortex)
5.293e-1 (AD)  4.530e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAPRIN20.853
PHTF10.851
ABCC50.842
FGFR1OP0.842
KIAA07530.839
ZNF5400.836
RIC30.835
NIPAL20.829
RABL2B0.828
RABL2A0.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.415
MDFI-0.412
HEY2-0.396
YES1-0.393
OR4F5-0.382
LRAT-0.38
SH2D1A-0.377
C9orf153-0.374
TFPI2-0.374
RHOD-0.373

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of NRG4 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of NRG4 mRNA"21354444|2890350
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of NRG4 mRNA"21920950
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NRG4 mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NRG4 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of NRG4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of NRG4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NRG4 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of NRG4 mRNA21757418
D000452AldrinAldrin results in decreased expression of NRG4 mRNA18579281
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of NRG4 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NRG4 mRNA26377693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NRG4 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of NRG4 mRNA19693291
C006780bisphenol Abisphenol A affects the expression of NRG4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NRG4 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NRG4 mRNA27339419
D019327Copper SulfateCopper Sulfate results in decreased expression of NRG4 mRNA18579281
D004008DiclofenacDiclofenac results in increased expression of NRG4 mRNA26934552
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NRG4 mRNA]"19467301
D004041Dietary FatsDietary Fats affects the expression of NRG4 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of NRG4 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of NRG4 mRNA19467301
D000431EthanolEthanol results in increased expression of NRG4 mRNA15513904
D005492Folic AcidFolic Acid results in decreased expression of NRG4 mRNA25006883
D008727MethotrexateMethotrexate affects the expression of NRG4 mRNA18502557
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of NRG4 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of NRG4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NRG4 mRNA"25620056
D000073878Palm OilPalm Oil affects the expression of NRG4 mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of NRG4 mRNA18042831
C016030pantogabpantogab results in increased expression of NRG4 mRNA17379144
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of NRG4 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of NRG4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of NRG4 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of NRG4 mRNA19270015
C006253pirinixic acidpirinixic acid results in increased expression of NRG4 mRNA17426115|1844570
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of NRG4 mRNA28903501
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NRG4 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of NRG4 mRNA23221170
C017947sodium arsenitesodium arsenite results in decreased expression of NRG4 mRNA21457566
D053260SootSoot results in decreased expression of NRG4 mRNA26551751
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NRG4 mRNA"18579281
C013698tallowtallow affects the expression of NRG4 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of NRG4 mRNA20937368
D013739TestosteroneTestosterone results in increased expression of NRG4 mRNA19693291
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of NRG4 mRNA]16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRG4 mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of NRG4 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NRG4 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NRG4 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NRG4 mRNA21215274
C009495titanium dioxidetitanium dioxide results in decreased expression of NRG4 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased expression of NRG4 mRNA25549359
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NRG4 mRNA29024780
D014520UrethaneUrethane results in decreased expression of NRG4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NRG4 mRNA17292431|1796380
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NRG4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI21516116  25416956  
GO:0008083growth factor activity-IEA-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0038128ERBB2 signaling pathway-TAS-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048513animal organ development-IBA21873635  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:2000145regulation of cell motility-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1227986Signaling by ERBB2TAS
R-HSA-1227986Signaling by ERBB2IEA
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1236394Signaling by ERBB4IEA
R-HSA-1250196SHC1 events in ERBB2 signalingIEA
R-HSA-1250196SHC1 events in ERBB2 signalingTAS
R-HSA-1250342PI3K events in ERBB4 signalingTAS
R-HSA-1250347SHC1 events in ERBB4 signalingTAS
R-HSA-1251985Nuclear signaling by ERBB4IEA
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1963640GRB2 events in ERBB2 signalingTAS
R-HSA-1963642PI3K events in ERBB2 signalingTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6785631ERBB2 Regulates Cell MotilityTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-8847993ERBB2 Activates PTK6 SignalingTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8863795Downregulation of ERBB2 signalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26230583Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress. (2015)Slattery MLPLoS One
27772531Association of circulating neuregulin 4 with metabolic syndrome in obese adults: a cross-sectional study. (2016 Oct 24)Cai CBMC Med
27819316Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults. (2016 Nov 7)Jiang JSci Rep