Gene: TTBK2

146057
SCA11|TTBK
tau tubulin kinase 2
protein-coding
15q15.2
Ensembl:ENSG00000128881 MIM:611695 Vega:OTTHUMG00000175802 UniprotKB:Q6IQ55
NG_012664.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.958e-1 (AD)  1.996e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12915116chr15:42782482 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7166775chr15:42750492 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEM1B0.946
RAPGEF20.944
RASA10.943
FAM126B0.942
PTPRK0.942
PDS5B0.94
COL4A3BP0.94
VPS350.94
AFTPH0.939
CAND10.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.509
OR4F29-0.469
AQP5-0.421
CSAG1-0.398
LRAT-0.386
HEY2-0.378
COPZ2-0.378
KLRB1-0.377
PINLYP-0.373
MDFI-0.372

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTBK2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTBK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTBK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTBK2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TTBK2 mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of TTBK2 mRNA19774075
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTBK2 mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of TTBK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TTBK2 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of TTBK2 gene28505145
D004390ChlorpyrifosChlorpyrifos results in increased expression of TTBK2 mRNA20691718
C018021cobaltous chloridecobaltous chloride results in increased expression of TTBK2 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of TTBK2 mRNA19549813
C014347decitabinedecitabine affects the expression of TTBK2 mRNA17145863
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TTBK2 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TTBK2 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of TTBK2 mRNA19167457
D019833GenisteinESR1 promotes the reaction [Genistein results in increased expression of TTBK2 protein]20884965
D019833GenisteinGenistein results in increased expression of TTBK2 protein20884965
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TTBK2 mRNA24796395
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TTBK2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TTBK2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TTBK2 mRNA"26251327
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of TTBK2 mRNA"29244179
C028007nickel monoxidenickel monoxide affects the expression of TTBK2 mRNA19167457
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of TTBK2 mRNA19095052
C014153pirimiphos methylpirimiphos methyl results in increased expression of TTBK2 mRNA27845199
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TTBK2 mRNA23608068
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TTBK2 mRNA21427059
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of TTBK2 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTBK2 mRNA22298810
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTBK2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TTBK2 mRNA26272509
D014520UrethaneUrethane results in increased expression of TTBK2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTBK2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TTBK2 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of TTBK2 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of TTBK2 mRNA19136453|2142705
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TTBK2 gene25560391
C111237vorinostatvorinostat results in decreased expression of TTBK2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA26323690  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA21548880  
GO:0004674protein serine/threonine kinase activity-NAS28386764  
GO:0005515protein binding-IPI22863007  25416956  26323690  
GO:0005524ATP binding-IEA-  
GO:0019894kinesin binding-IPI26323690  
GO:0050321tau-protein kinase activity-TAS26323690  
GO:0051010microtubule plus-end binding-TAS26323690  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IGI26323690  
GO:0007026negative regulation of microtubule depolymerization-IDA26323690  
GO:0007224smoothened signaling pathway-ISS-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IDA21548880  26323690  
GO:0021549cerebellum development-ISS26323690  
GO:0021681cerebellar granular layer development-ISS26323690  
GO:0021935cerebellar granule cell precursor tangential migration-ISS26323690  
GO:0030334regulation of cell migration-IGI26323690  
GO:0060271cilium assembly-IMP23141541  
GO:0060271cilium assembly-ISS-  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:1902817negative regulation of protein localization to microtubule-IMP26323690  
GO:1904527negative regulation of microtubule binding-IDA26323690  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA21548880  
GO:0005737cytoplasm-IBA21873635  
GO:0005814centriole-IDA23141541  
GO:0005829cytosol-IDA21548880  
GO:0005829cytosol-TAS-  
GO:0035869ciliary transition zone-IDA23141541  
GO:0035869ciliary transition zone-ISS-  
GO:0036064ciliary basal body-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal