Gene: TEKT5

146279
CT149
tektin 5
protein-coding
16p13.13
Ensembl:ENSG00000153060 Vega:OTTHUMG00000129750 UniprotKB:Q96M29
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.430e-1 (AD)  4.638e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4780986chr16:10721373 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCL130.574
CRABP20.522
ADAM320.521
CEACAM190.52
B4GALNT30.509
MYBPHL0.504
AQP80.502
FGF170.498
SLC43A10.498
AP1G20.496

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFRP1-0.308
TIGIT-0.306
KLRB1-0.287
NOS1-0.279
SH2D1A-0.278
PDE11A-0.277
BCHE-0.27
LUZP2-0.265
HMSD-0.259
NCKAP5-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of TEKT5 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TEKT5 gene27153756
D001151ArsenicArsenic affects the methylation of TEKT5 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TEKT5 mRNA21715664|2261060
C006780bisphenol Abisphenol A results in decreased expression of TEKT5 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TEKT5 promoter22457795
D003907DexamethasoneDexamethasone results in increased expression of TEKT5 mRNA22733784
D004397FonofosFonofos results in increased methylation of TEKT5 promoter22847954
D010278ParathionParathion results in increased methylation of TEKT5 promoter22847954
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TEKT5 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of TEKT5 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TEKT5 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in increased expression of TEKT5 mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of TEKT5 protein28918527
C012568terbufosterbufos results in increased methylation of TEKT5 promoter22847954

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0030317flagellated sperm motility-IBA21873635  
GO:0060271cilium assembly-IBA21873635  
GO:0060294cilium movement involved in cell motility-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0036126sperm flagellum-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal