Gene: GSG1L

146395
PRO19651
GSG1 like
protein-coding
16p12.1
Ensembl:ENSG00000169181 MIM:617161 Vega:OTTHUMG00000131676 UniprotKB:Q6UXU4
NC_000016.10
PubMed
0   ANCO-SNPs
OD|CD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.209e-1 (AD)  6.270e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AMPD20.81
CPNE50.785
CHD30.783
PDE2A0.776
HPCAL40.773
GNPTAB0.773
MBTPS10.772
MAPK10.772
CAMKV0.77
JPH40.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.519
OR4F29-0.464
PDZK1IP1-0.334
CXCL3-0.328
FLT3LG-0.323
GDF15-0.322
RAI14-0.313
EVC2-0.308
S100A14-0.307
SNHG18-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GSG1L mRNA"25614096
D000082AcetaminophenAcetaminophen results in decreased expression of GSG1L mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of GSG1L mRNA28959563
D001280AtrazineAtrazine results in decreased expression of GSG1L mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GSG1L mRNA21839799
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GSG1L mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GSG1L mRNA]25566086
C006780bisphenol Abisphenol A affects the expression of GSG1L mRNA21786754
C006780bisphenol Abisphenol A affects the expression of GSG1L mRNA25181051
D003471CuprizoneCuprizone results in increased expression of GSG1L mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GSG1L mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GSG1L mRNA21266533
D005839GentamicinsGentamicins results in decreased expression of GSG1L mRNA22061828
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GSG1L mRNA"20188158
C523799MRK 003GSG1L results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GSG1L mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GSG1L mRNA"25554681
D053260SootSoot results in decreased expression of GSG1L mRNA26551751
C009495titanium dioxidetitanium dioxide results in decreased expression of GSG1L mRNA27760801
D014635Valproic AcidValproic Acid results in increased methylation of GSG1L gene29154799
D014635Valproic AcidValproic Acid affects the expression of GSG1L mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:2000311regulation of AMPA receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0099061integral component of postsynaptic density membrane-IBA21873635  
GO:0099061integral component of postsynaptic density membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26658868Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. (2015 Dec 9)McGee TPJ Neurosci
27010727Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients. (2016 Mar)Yang HCPLoS Genet