Gene: MGAT5B

146664
GnT-IX|GnT-VB
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
protein-coding
17q25.2
Ensembl:ENSG00000167889 MIM:612441 Vega:OTTHUMG00000177278 UniprotKB:Q3V5L5
NC_000017.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.596e-1 (AD)  8.168e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2411042chr17:76917855 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02341119chr17:74866479MGAT5B8.150e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAMK2A0.948
CAMKK20.94
KCNAB20.939
FBXO410.936
CACNB30.936
RIMS30.935
KNDC10.933
POU6F10.932
KCNH30.931
GABRD0.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SGMS2-0.601
ANXA13-0.577
VRK2-0.563
SNHG18-0.562
IGF2BP2-0.553
SH2D1A-0.544
SEPT10-0.539
WIPF1-0.534
C9orf135-0.532
DTHD1-0.526

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MGAT5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MGAT5B mRNA"27188386
C015001arsenitearsenite results in increased methylation of MGAT5B promoter23974009
C006780bisphenol Abisphenol A results in increased expression of MGAT5B mRNA27685785
C006780bisphenol Abisphenol A results in increased methylation of MGAT5B promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of MGAT5B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MGAT5B gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of MGAT5B mRNA26079696
D003471CuprizoneCuprizone results in decreased expression of MGAT5B mRNA27523638
D003471CuprizoneCuprizone results in increased expression of MGAT5B mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of MGAT5B promoter27989131
D003976DiazinonDiazinon results in increased methylation of MGAT5B gene22964155
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MGAT5B intron27776689
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of MGAT5B mRNA26378955
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MGAT5B mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MGAT5B mRNA29191790
D016686MonocrotalineMonocrotaline results in increased expression of MGAT5B mRNA28818515
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of MGAT5B protein24625837
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MGAT5B mRNA"27188386
D011441PropylthiouracilPropylthiouracil results in increased expression of MGAT5B mRNA24780913
D012715Sesame OilSesame Oil results in increased expression of MGAT5B mRNA29191790
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of MGAT5B mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MGAT5B mRNA21570461
C012589trichostatin Atrichostatin A results in increased expression of MGAT5B mRNA24619417
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MGAT5B mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of MGAT5B mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23088713  
GO:0030144alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006487protein N-linked glycosylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00510N-Glycan biosynthesis
hsa00514Other types of O-glycan biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal