Gene: B3GNTL1

146712
3-Gn-T8|B3GNT8|BGnT-8|beta-1|beta3Gn-T8|beta3GnTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1
protein-coding
17q25.3
Ensembl:ENSG00000175711 MIM:615337 Vega:OTTHUMG00000177788 UniprotKB:Q67FW5
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
1.928e-1 (AD)  3.756e-1 (ND)   (Frontal_Cortex)
2.185e-1 (AD)  3.467e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1143006chr17:83048511 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07103846chr17:80970159B3GNTL1Gene body3.825e-4Alcohol use disorders26763658
cg20663495chr17:80943851B3GNTL19.480e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBC1D250.869
ME30.865
KATNB10.857
ENTPD60.857
HPS60.857
RABGGTA0.856
C2CD2L0.855
SLC27A40.854
DGKQ0.854
AP3B20.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.519
RAI14-0.512
REST-0.495
CNN2-0.484
WWTR1-0.458
MTRNR2L6-0.454
HEY2-0.447
CLEC2B-0.447
MTRNR2L9-0.446
NEDD4-0.444

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of B3GNTL1 mRNA"25575267
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of B3GNTL1 mRNA"25575267
D020106AcrylamideAcrylamide results in increased expression of B3GNTL1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of B3GNTL1 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of B3GNTL1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of B3GNTL1 mRNA24449571
D001151ArsenicArsenic affects the methylation of B3GNTL1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of B3GNTL1 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of B3GNTL1 mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of B3GNTL1 mRNA25575267
C006780bisphenol Abisphenol A affects the expression of B3GNTL1 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of B3GNTL1 mRNA25575267
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of B3GNTL1 promoter22457795
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of B3GNTL1 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of B3GNTL1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of B3GNTL1 mRNA27392435
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of B3GNTL1 mRNA25575267
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of B3GNTL1 mRNA22079256
D004964EstriolEstriol results in decreased expression of B3GNTL1 mRNA25575267
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of B3GNTL1 mRNA20170705
C492448ICG 001ICG 001 results in decreased expression of B3GNTL1 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of B3GNTL1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of B3GNTL1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of B3GNTL1 mRNA23430699
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of B3GNTL1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of B3GNTL1 promoter"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of B3GNTL1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of B3GNTL1 mRNA"25620056
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of B3GNTL1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of B3GNTL1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of B3GNTL1 mRNA19162173
D011794QuercetinQuercetin results in decreased expression of B3GNTL1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of B3GNTL1 mRNA22574217
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of B3GNTL1 mRNA28065790
D014635Valproic AcidValproic Acid results in increased methylation of B3GNTL1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of B3GNTL1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016757transferase activity, transferring glycosyl groups-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal