Gene: DNAH2

146754
DNAHC2|DNHD3
dynein axonemal heavy chain 2
protein-coding
17p13.1
Ensembl:ENSG00000183914 MIM:603333 Vega:OTTHUMG00000178020 UniprotKB:Q9P225
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.528e-1 (AD)  7.427e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12453814chr17:7761975 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAT20.727
DGKA0.703
PLB10.695
CSMD20.69
TMEM74B0.673
PIGL0.655
OBSCN0.652
SPAG170.646
WNT10.646
GOLGA8A0.635

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDKN2C-0.397
LHPP-0.369
ALDH1A1-0.366
ASCL1-0.355
HES6-0.34
RFTN2-0.337
HOMER3-0.318
S100A1-0.315
KIF1C-0.313
MCM7-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of DNAH2 mRNA17562736
C016601afimoxifeneDNAH2 results in decreased susceptibility to afimoxifene21233418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DNAH2 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of DNAH2 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of DNAH2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of DNAH2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DNAH2 mRNA22228805
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DNAH2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of DNAH2 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of DNAH2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH2 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of DNAH2 mRNA26577399
D003561CytarabineCytarabine results in decreased expression of DNAH2 mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DNAH2 mRNA28628672
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH2 mRNA20938992
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DNAH2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DNAH2 mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH2 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DNAH2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DNAH2 mRNA"25554681
D011441PropylthiouracilPropylthiouracil results in increased expression of DNAH2 mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of DNAH2 protein28918527
D053260SootSoot results in decreased expression of DNAH2 mRNA26551751
C009495titanium dioxidetitanium dioxide affects the expression of DNAH2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DNAH2 mRNA28065790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DNAH2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DNAH2 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of DNAH2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of DNAH2 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of DNAH2 mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-NAS9256245  
GO:0005524ATP binding-IEA-  
GO:0008569ATP-dependent microtubule motor activity, minus-end-directed-IBA21873635  
GO:0045503dynein light chain binding-IBA21873635  
GO:0045505dynein intermediate chain binding-IBA21873635  
GO:0051959dynein light intermediate chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IBA21873635  
GO:0060285cilium-dependent cell motility-NAS9256245  
GO ID GO Term Qualifier Evidence PubMed
GO:0005858axonemal dynein complex-NAS9256245  
GO:0005874microtubule-IEA-  
GO:0030286dynein complex-IBA21873635  
GO:0031514motile cilium-IBA21873635  
KEGG ID KEGG Term
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal