Gene: KCTD11

147040
C17orf36|KCASH1|REN|REN/KCTD11
potassium channel tetramerization domain containing 11
protein-coding
17p13.1
Ensembl:ENSG00000213859 MIM:609848 Vega:OTTHUMG00000132061 UniprotKB:Q693B1
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.895e-1 (AD)  8.253e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNAP230.793
MAPKAPK20.78
CSF10.765
NECAP20.745
MSN0.741
EVC20.738
LRP100.734
SRGAP10.734
NOTCH10.733
NXT20.731

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNS2-0.512
KCNB2-0.497
CHRNB2-0.483
CDH8-0.48
PTPRR-0.479
STXBP5L-0.478
FAM19A1-0.477
STYK1-0.475
HTR2A-0.475
TMEM132D-0.472

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCTD11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCTD11 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of KCTD11 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of KCTD11 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KCTD11 mRNA21641981|2210060
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KCTD11 mRNA25908611
C006780bisphenol Abisphenol A results in increased expression of KCTD11 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride affects the expression of KCTD11 mRNA18974090
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCTD11 gene20938992
D003033Coal TarCoal Tar results in decreased expression of KCTD11 mRNA27858113
D003471CuprizoneCuprizone results in decreased expression of KCTD11 mRNA26577399
D002945CisplatinCisplatin results in increased expression of KCTD11 mRNA27392435
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KCTD11 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCTD11 gene20938992
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KCTD11 mRNA24796395
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCTD11 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KCTD11 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KCTD11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KCTD11 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of KCTD11 mRNA20042640
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KCTD11 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of KCTD11 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of KCTD11 mRNA27029645
D012834SilverSilver results in increased expression of KCTD11 mRNA26014281
D014212TretinoinTretinoin results in increased expression of KCTD11 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of KCTD11 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KCTD11 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of KCTD11 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCTD11 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KCTD11 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KCTD11 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of KCTD11 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KCTD11 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016740transferase activity-IEA-  
GO:0042802identical protein binding-IPI27152988  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0040008regulation of growth-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21203850Copy number variations of chromosome 17p13.1 might be linked to high risk of lung cancer in heavy smokers. (2011 Nov)Lee MMol Biol Rep