Gene: TMC8

147138
EV2|EVER2|EVIN2
transmembrane channel like 8
protein-coding
17q25.3
Ensembl:ENSG00000167895 MIM:605829 Vega:OTTHUMG00000177436 UniprotKB:Q8IU68
NG_007881.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.914e-1 (AD)  6.926e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO1F0.907
RASAL30.903
PARVG0.89
CD370.888
WAS0.879
HCLS10.868
DOCK20.866
PRAM10.864
SYK0.862
ARHGAP300.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCD2-0.432
MARCH4-0.421
C9orf24-0.413
POU3F1-0.411
CRH-0.409
WNT7A-0.406
ST6GALNAC5-0.406
NEUROD6-0.4
B3GALT1-0.398
YBX2-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TMC8 mRNA"20816883
D000082AcetaminophenAcetaminophen results in increased expression of TMC8 mRNA26690555
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TMC8 mRNA24449571
D001151ArsenicArsenic affects the expression of TMC8 mRNA18414638
D001379AzathioprineAzathioprine results in increased expression of TMC8 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TMC8 gene25435355
C006780bisphenol Abisphenol A results in decreased methylation of TMC8 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of TMC8 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TMC8 mRNA26079696
D019327Copper SulfateCopper Sulfate results in increased expression of TMC8 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of TMC8 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of TMC8 mRNA25562108
D004041Dietary FatsDietary Fats results in increased expression of TMC8 mRNA25016146
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TMC8 mRNA22634610
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TMC8 mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TMC8 mRNA"24972896
D009532NickelNickel results in increased expression of TMC8 mRNA24768652|2558310
C005556propionaldehydepropionaldehyde results in increased expression of TMC8 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TMC8 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMC8 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TMC8 promoter]19654925
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TMC8 mRNA29024780
D014635Valproic AcidValproic Acid results in increased methylation of TMC8 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI23429285  
GO:0005216ion channel activity-IBA21873635  
GO:0005515protein binding-IPI18158319  
GO:0008381mechanosensitive ion channel activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IDA18158319  
GO:0006811ion transport-IEA-  
GO:0032091negative regulation of protein binding-IDA23429285  
GO:0032460negative regulation of protein oligomerization-IDA23429285  
GO:0055069zinc ion homeostasis-IDA18158319  
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors-IDA23429285  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005737cytoplasm-IDA12426567  
GO:0005783endoplasmic reticulum-IDA12426567  18158319  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005794Golgi apparatus-IDA18158319  
GO:0005887integral component of plasma membrane-IEA-  
GO:0031965nuclear membrane-IDA18158319  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29212247A six-mRNA signature model for the prognosis of head and neck squamous cell carcinoma. (2017 Nov 7)Guo WOncotarget