Gene: CCBE1

147372
HKLLS1
collagen and calcium binding EGF domains 1
protein-coding
18q21.32
Ensembl:ENSG00000183287 MIM:612753 Vega:OTTHUMG00000180087 UniprotKB:Q6UXH8
NG_016990.1
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.283e-2 (AD)  5.100e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2852356chr18:59692901 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs1944980chr18:59616901 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNGB10.632
ANKRD60.626
C1QL30.611
HTR1A0.604
MS4A80.603
GRM10.602
STXBP50.597
LRRC20.593
TMEM200A0.589
ADAMTS30.587

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.36
CNN2-0.342
SERTAD3-0.337
C19orf18-0.329
SLC43A3-0.329
C1QTNF1-0.328
SNHG18-0.328
PGF-0.325
FLT3LG-0.319
SGMS2-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CCBE1 mRNA19933214
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of CCBE1 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCBE1 mRNA"27188386
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CCBE1 mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CCBE1 mRNA23626723
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCBE1 mRNA"27188386
D000393Air PollutantsAir Pollutants analog results in increased expression of CCBE1 mRNA21757418
C547126AZM551248AZM551248 results in increased expression of CCBE1 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CCBE1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CCBE1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCBE1 mRNA22178795
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CCBE1 mRNA27858113
C006780bisphenol Abisphenol A results in decreased expression of CCBE1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CCBE1 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of CCBE1 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of CCBE1 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CCBE1 mRNA17484886
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CCBE1 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of CCBE1 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CCBE1 mRNA27858113
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CCBE1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CCBE1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CCBE1 mRNA25016146
C024565ethylene dichlorideethylene dichloride results in decreased expression of CCBE1 mRNA28189721
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CCBE1 mRNA24657277
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CCBE1 mRNA21179406
C492448ICG 001ICG 001 results in increased expression of CCBE1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCBE1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CCBE1 mRNA27392435
D007840LatexLatex analog results in decreased expression of CCBE1 mRNA24768652
C030272maleic acidmaleic acid results in increased expression of CCBE1 mRNA28392987
C042720mercuric bromidemercuric bromide results in decreased expression of CCBE1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CCBE1 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of CCBE1 mRNA24657277
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of CCBE1 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CCBE1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCBE1 mRNA"25554681
D010634PhenobarbitalPhenobarbital affects the expression of CCBE1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCBE1 mRNA"27188386
C005556propionaldehydepropionaldehyde results in increased expression of CCBE1 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CCBE1 mRNA25895662
D018038Sodium SeleniteSodium Selenite results in decreased expression of CCBE1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCBE1 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCBE1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CCBE1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CCBE1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CCBE1 mRNA19969065
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CCBE1 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of CCBE1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of CCBE1 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of CCBE1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CCBE1 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCBE1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CCBE1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CCBE1 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI24552833  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0005518collagen binding-IDA21778431  
GO ID GO Term Qualifier Evidence PubMed
GO:0001946lymphangiogenesis-IMP19935664  
GO:0001946lymphangiogenesis-ISS-  
GO:0002040sprouting angiogenesis-ISS-  
GO:0003016respiratory system process-IEA-  
GO:0010575positive regulation of vascular endothelial growth factor production-IDA24552833  
GO:0010595positive regulation of endothelial cell migration-IEA-  
GO:0010954positive regulation of protein processing-IDA24552833  
GO:0030324lung development-IEA-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0048845venous blood vessel morphogenesis-ISS-  
GO:1900748positive regulation of vascular endothelial growth factor signaling pathway-IDA24552833  
GO:1901492positive regulation of lymphangiogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005581collagen trimer-IEA-  
GO:0005615extracellular space-IDA24552833  
GO:0031012extracellular matrix-IDA21778431  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal