Gene: CBLN2

147381
-
cerebellin 2 precursor
protein-coding
18q22.3
Ensembl:ENSG00000141668 MIM:600433 Vega:OTTHUMG00000132825 UniprotKB:Q8IUK8
NC_000018.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.484e-1 (AD)  3.874e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TESPA10.965
KCNJ30.949
ENC10.949
FAM19A10.946
CHRM30.945
GABBR20.944
SYT130.943
KIAA1549L0.941
FAM81A0.941
MEF2C0.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAP1-0.581
ARHGEF5-0.559
WWTR1-0.554
TFPI2-0.554
HEY2-0.545
CNN2-0.543
RAI14-0.54
REST-0.536
MYL3-0.53
YES1-0.525

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CBLN2 mRNA"19114083
D020106AcrylamideAcrylamide results in decreased expression of CBLN2 mRNA28959563
D001280AtrazineAtrazine results in decreased expression of CBLN2 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CBLN2 mRNA21802500
C006780bisphenol Abisphenol A results in decreased expression of CBLN2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CBLN2 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CBLN2 gene20938992
D003010ClorgylineClorgyline results in increased expression of CBLN2 mRNA19691856
D003976DiazinonDiazinon results in increased expression of CBLN2 mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CBLN2 mRNA21266533
D019422Dietary SucroseDietary Sucrose results in increased expression of CBLN2 mRNA26033743
D002117CalcitriolCalcitriol results in decreased expression of CBLN2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CBLN2 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CBLN2 mRNA"19480007
C118739entinostatentinostat results in decreased expression of CBLN2 mRNA27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CBLN2 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CBLN2 gene20938992
C039281furanfuran results in decreased expression of CBLN2 mRNA25539665
C039281furanfuran results in increased methylation of CBLN2 gene22079235
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of CBLN2 mRNA22467014
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CBLN2 gene20938992
D009532NickelNickel results in decreased expression of CBLN2 mRNA24768652
D011441PropylthiouracilPropylthiouracil affects the expression of CBLN2 mRNA24780913
D012402RotenoneRotenone results in decreased expression of CBLN2 mRNA19013527
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CBLN2 mRNA25895662
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of CBLN2 mRNA22467014
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CBLN2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CBLN2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CBLN2 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBLN2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CBLN2 mRNA17942748
D019284ThapsigarginThapsigargin results in decreased expression of CBLN2 mRNA22378314
D014212TretinoinTretinoin results in decreased expression of CBLN2 mRNA23724009
D014415TunicamycinTunicamycin results in decreased expression of CBLN2 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of CBLN2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CBLN2 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of CBLN2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CBLN2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0051965positive regulation of synapse assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26173551A New Genomewide Association Meta-Analysis of Alcohol Dependence. (2015 Aug)Zuo LAlcohol Clin Exp Res