Gene: CSTA

1475
AREI|PSS4|STF1|STFA
cystatin A
protein-coding
3q21.1
Ensembl:ENSG00000121552 MIM:184600 Vega:OTTHUMG00000159488 UniprotKB:P01040
NG_027995.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.433e-2 (AD)  2.085e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPINK50.817
KRT150.813
MUC210.794
SERPINB30.771
ADH70.757
KLK130.754
TMPRSS11B0.754
CRNN0.745
KRT40.745
GBP60.739

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM163B-0.344
GNG13-0.329
RNFT2-0.327
SYT3-0.326
RORB-0.325
ZNF425-0.321
ZNF835-0.32
CCDC113-0.32
CCDC87-0.318
HIPK4-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CSTA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CSTA mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CSTA mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of CSTA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CSTA protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CSTA mRNA21632981|2164198
D000447AldehydesAldehydes results in increased expression of CSTA mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of CSTA protein16483693
D000667AmpicillinAmpicillin results in decreased expression of CSTA mRNA21632981
C006632arsenic trioxidearsenic trioxide affects the expression of CSTA mRNA27825931
C006632arsenic trioxidearsenic trioxide results in increased expression of CSTA mRNA20458559|2435693
D001241AspirinAspirin results in increased expression of CSTA mRNA15456535|1592858
D001379AzathioprineAzathioprine results in increased expression of CSTA mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of CSTA mRNA24356939
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CSTA mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CSTA mRNA22342234
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CSTA mRNA19619570
D004958EstradiolEstradiol results in decreased expression of CSTA mRNA15072547
D004958EstradiolEstradiol results in increased expression of CSTA mRNA19619570|2010694
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CSTA mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CSTA mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of CSTA mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of CSTA mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CSTA mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of CSTA mRNA27825931
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CSTA mRNA20971185
D019327Copper SulfateCopper Sulfate affects the expression of CSTA mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of CSTA mRNA27825931
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of CSTA mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of CSTA mRNA19167446
C030973cupric oxidecupric oxide results in increased expression of CSTA mRNA22077320
D003520CyclophosphamideCyclophosphamide metabolite results in decreased expression of CSTA mRNA24356939
D016572CyclosporineCyclosporine results in increased expression of CSTA mRNA20106945|2163298
D003703DemecolcineDemecolcine results in increased expression of CSTA mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CSTA mRNA28628672
D002945CisplatinCisplatin affects the expression of CSTA mRNA27825931
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CSTA mRNA27392435
D002945CisplatinCisplatin results in increased expression of CSTA mRNA27392435|2759478
C000944dicrotophosdicrotophos results in decreased expression of CSTA mRNA28302478
D019422Dietary SucroseDietary Sucrose results in increased expression of CSTA mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol affects the expression of CSTA mRNA27825931
D004317DoxorubicinDoxorubicin results in increased expression of CSTA mRNA27825931
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CSTA mRNA23649840
D0150732-Acetylaminofluorene2-Acetylaminofluorene affects the expression of CSTA mRNA27825931
D005557FormaldehydeFormaldehyde results in increased expression of CSTA mRNA23649840
C070081fulvestrantfulvestrant results in decreased expression of CSTA mRNA15072547
D019833GenisteinGenistein results in increased expression of CSTA mRNA20884965
C475919hydroxytamoxifenhydroxytamoxifen results in decreased expression of CSTA mRNA15072547
D006918HydroxyureaHydroxyurea affects the expression of CSTA mRNA27825931
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CSTA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CSTA mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CSTA mRNA27392435
C410337K 7174K 7174 results in increased expression of CSTA mRNA24086573
D007854LeadCSTA protein binds to Lead23896426
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CSTA mRNA"24972896
D008727MethotrexateCSTA protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateMethotrexate results in increased expression of CSTA mRNA17379860
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CSTA mRNA23649840
C523799MRK 003CSTA results in increased susceptibility to MRK 00319903844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of CSTA mRNA"29244179
C022838nickel chloridenickel chloride affects the expression of CSTA mRNA27825931
C029938nickel sulfatenickel sulfate results in decreased expression of CSTA mRNA18651567
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CSTA mRNA20971185
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of CSTA mRNA24356939
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CSTA mRNA26705709
C046012pentanalpentanal results in increased expression of CSTA mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CSTA mRNA25868421
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of CSTA mRNA17097637
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CSTA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CSTA mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CSTA mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of CSTA mRNA18070364
C005556propionaldehydepropionaldehyde results in increased expression of CSTA mRNA26079696
D011794QuercetinQuercetin results in increased expression of CSTA mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of CSTA mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of CSTA mRNA19167446
D012643SeleniumSelenium results in decreased expression of CSTA mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of CSTA mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CSTA mRNA25895662
D012906SmokeSmoke results in decreased expression of CSTA mRNA21095227
C016104sodium bichromatesodium bichromate affects the expression of CSTA mRNA27825931
D018038Sodium SeleniteSodium Selenite results in increased expression of CSTA mRNA24383545
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CSTA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CSTA mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CSTA mRNA19619570
D014212TretinoinTretinoin results in increased expression of CSTA mRNA17218384|2383079
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CSTA mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CSTA mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of CSTA mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CSTA gene25560391
D014750VincristineVincristine results in increased expression of CSTA mRNA23649840
D019287Zinc SulfateZinc Sulfate results in increased expression of CSTA mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI6203523  
GO:0004869cysteine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004869cysteine-type endopeptidase inhibitor activity-IDA3488317  6203523  
GO:0005198structural molecule activity-IDA10908733  
GO:0030674protein binding, bridging-IDA10908733  
GO ID GO Term Qualifier Evidence PubMed
GO:0010466negative regulation of peptidase activity-IDA6203523  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0018149peptide cross-linking-IDA10908733  
GO:0030216keratinocyte differentiation-IDA10908733  
GO:0045861negative regulation of proteolysis-IDA3488317  
GO:0070268cornification-TAS-  
GO:0098609cell-cell adhesion-IMP21944047  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IDA10908733  
GO:0001533cornified envelope-TAS-  
GO:0005615extracellular space-IDA3488317  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IDA21944047  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21325429Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer. (2011 Apr 1)Butler MWCancer Res