Gene: CSTB

1476
CPI-B|CST6|EPM1|EPM1A|PME|STFB|ULD
cystatin B
protein-coding
21q22.3
Ensembl:ENSG00000160213 MIM:601145 Vega:OTTHUMG00000086886 UniprotKB:P04080
NG_011545.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.838e-1 (AD)  2.129e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSTP10.927
OST40.925
POLR2J0.923
PRDX10.9
DAD10.9
BRI30.9
PSENEN0.899
CD810.898
ZMAT50.894
PPIB0.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.778
OR4F29-0.756
PP2D1-0.236
KLHL14-0.221
PCDHAC1-0.207
CDH7-0.197
IL1RAPL2-0.192
ATP12A-0.19
HCRTR1-0.184
NXPH2-0.183

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09131Cupric ChlorideSmall Molecule7447-39-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CSTB mRNA"19162173
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of CSTB mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of CSTB mRNA]"19414516
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of CSTB mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CSTB mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in increased expression of CSTB mRNA15890375
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of CSTB mRNA"24172598
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CSTB mRNA"18648102
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CSTB mRNA15890375
D000082AcetaminophenAcetaminophen affects the expression of CSTB mRNA17562736
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of CSTB mRNA]"19414516
D000255Adenosine Triphosphate"Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]"25288807
D000255Adenosine Triphosphate"Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein]"25288807
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CSTB mRNA15890375
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CSTB mRNA28522335
D000499AllylamineAllylamine affects the expression of CSTB mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CSTB mRNA16483693
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of CSTB mRNA18585445
C006632arsenic trioxidearsenic trioxide results in decreased expression of CSTB protein19364129
D001280AtrazineAtrazine results in increased expression of CSTB mRNA25929836
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of CSTB mRNA18585445
C547126AZM551248AZM551248 results in increased expression of CSTB mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CSTB mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CSTB mRNA22228805
D004958EstradiolEstradiol results in increased expression of CSTB mRNA14664709|1528915
C006780bisphenol Abisphenol A results in decreased expression of CSTB mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of CSTB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CSTB gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CSTB mRNA18804290
C584509C646 compoundC646 compound results in decreased expression of CSTB mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CSTB mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CSTB promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CSTB mRNA27339419
C100187chloropicrinchloropicrin results in decreased expression of CSTB mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CSTB mRNA20938992
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of CSTB mRNA16197558
D019327Copper SulfateCopper Sulfate results in decreased expression of CSTB mRNA19549813
C029892cupric chlorideCSTB protein binds to cupric chloride16939620
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CSTB mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of CSTB mRNA25562108
D013759DronabinolDronabinol results in increased expression of CSTB mRNA18163980
D013759DronabinolDronabinol results in increased expression of CSTB protein18163980
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CSTB protein16344271
D003976DiazinonDiazinon results in increased methylation of CSTB gene22964155
D003976DiazinonDiazinon affects the expression of CSTB mRNA22546817
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of CSTB mRNA"25908611
D004026DieldrinDieldrin affects the expression of CSTB mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of CSTB mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CSTB mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CSTB mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CSTB mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CSTB mRNA15890375
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CSTB mRNA15890375
D004237DiuronDiuron metabolite results in increased expression of CSTB mRNA24172598
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CSTB protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CSTB mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CSTB mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSTB mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CSTB mRNA16174780
C540355fenamidonefenamidone results in increased expression of CSTB mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CSTB mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of CSTB mRNA23649840
C056933fumonisin B1fumonisin B1 results in increased expression of CSTB mRNA16221962
D019833GenisteinGenistein results in increased expression of CSTB mRNA15289156
D005839GentamicinsGentamicins results in increased expression of CSTB mRNA22061828
D006118GriseofulvinGriseofulvin results in increased expression of CSTB mRNA12735108
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CSTB mRNA25613284
C544151jinfukangjinfukang results in increased expression of CSTB mRNA27392435
C410337K 7174K 7174 results in decreased expression of CSTB mRNA24086573
D001556LindaneLindane results in increased expression of CSTB mRNA18804290
C482199lipopolysaccharide, E coli O55-B5"Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]"25288807
C482199lipopolysaccharide, E coli O55-B5"Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein]"25288807
C482199lipopolysaccharide, E coli O55-B5"CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5"25288807
C482199lipopolysaccharide, E coli O55-B5"[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein"25288807
C482199lipopolysaccharide, E coli O55-B5"[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein"25288807
C482199lipopolysaccharide, E coli O55-B5"[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased expression of CASP4 mRNA"25288807
C482199lipopolysaccharide, E coli O55-B5"[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased expression of IFNG mRNA"25288807
C482199lipopolysaccharide, E coli O55-B5"[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL18 protein"25288807
C482199lipopolysaccharide, E coli O55-B5"[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL1B protein"25288807
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the localization of CSTB protein"25288807
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CSTB mRNA27339419
D008694MethamphetamineMethamphetamine affects the expression of CSTB protein17904249
D008701MethapyrileneMethapyrilene results in increased expression of CSTB mRNA15890375
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CSTB mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CSTB mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CSTB mRNA23103053
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CSTB protein26558463
D009020MorphineMorphine results in decreased expression of CSTB protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CSTB protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CSTB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CSTB mRNA"25554681
D009532NickelNickel results in increased expression of CSTB mRNA12540486
C022838nickel chloridenickel chloride affects the expression of CSTB mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of CSTB mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of CSTB mRNA18042831
D052638Particulate MatterParticulate Matter results in decreased expression of CSTB mRNA15046786
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CSTB mRNA18804290
D010578PetroleumPetroleum affects the expression of CSTB mRNA25208076
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CSTB mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CSTB mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of CSTB mRNA19482888
D010705PhosgenePhosgene affects the expression of CSTB mRNA16300373
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of CSTB mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of CSTB mRNA16221962|1830175
C006253pirinixic acidpirinixic acid results in decreased expression of CSTB mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of CSTB mRNA15890375
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CSTB mRNA19162173
C045950propiconazolepropiconazole results in increased expression of CSTB mRNA21278054
D015474IsotretinoinIsotretinoin results in decreased expression of CSTB mRNA20436886
D012524SarinSarin results in decreased expression of CSTB mRNA19522546
D012524SarinSarin results in increased expression of CSTB mRNA19522546
D053260SootSoot results in increased expression of CSTB mRNA22461453
D013629TamoxifenTamoxifen affects the expression of CSTB mRNA14699072
D013629TamoxifenTamoxifen affects the expression of CSTB mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSTB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CSTB mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CSTB mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of CSTB protein20109541
C009495titanium dioxidetitanium dioxide results in increased expression of CSTB mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CSTB mRNA20133372
C066340tolcaponetolcapone results in decreased expression of CSTB mRNA24136188
D014118Toxins, Biological"Toxins, Biological affects the expression of CSTB mRNA"19682533
C012589trichostatin Atrichostatin A affects the expression of CSTB mRNA28542535
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CSTB mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of CSTB mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of CSTB gene29154799
D014640VancomycinVancomycin results in decreased expression of CSTB mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CSTB mRNA15046786
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CSTB gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of CSTB mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of CSTB mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI6203523  
GO:0003723RNA binding-HDA22658674  
GO:0004866endopeptidase inhibitor activity-TAS3053245  
GO:0004869cysteine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004869cysteine-type endopeptidase inhibitor activity-IDA3488317  6203523  
GO ID GO Term Qualifier Evidence PubMed
GO:0008344adult locomotory behavior-IEA-  
GO:0010466negative regulation of peptidase activity-IDA6203523  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045861negative regulation of proteolysis-IDA3488317  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA23580065  
GO:0005615extracellular space-IDA3488317  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA11139332  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0034774secretory granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:1904724tertiary granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal