Gene: SPC24

147841
SPBC24
SPC24, NDC80 kinetochore complex component
protein-coding
19p13.2
Ensembl:ENSG00000161888 MIM:609394 Vega:OTTHUMG00000180798 UniprotKB:Q8NBT2
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.615e-1 (AD)  6.788e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AMER30.695
YPEL40.694
FRAT10.679
LRRC200.679
BCL7A0.674
PTK2B0.668
RAB370.666
WDR540.663
NRXN10.663
DENND6B0.663

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.458
SGMS2-0.409
WWTR1-0.409
TFPI2-0.405
C9orf135-0.399
YES1-0.391
MORC4-0.391
HAS2-0.389
ZNF114-0.387
DOK2-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPC24 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of SPC24 mRNA"19095052
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SPC24 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPC24 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPC24 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPC24 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPC24 mRNA"25510870
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of SPC24 mRNA"24172598
D000082AcetaminophenAcetaminophen results in decreased expression of SPC24 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of SPC24 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SPC24 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SPC24 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of SPC24 mRNA24535564
C547126AZM551248AZM551248 results in increased expression of SPC24 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SPC24 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPC24 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SPC24 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of SPC24 mRNA18310284
C006780bisphenol Abisphenol A affects the expression of SPC24 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SPC24 mRNA29275510
C018475butyraldehydebutyraldehyde results in decreased expression of SPC24 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SPC24 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SPC24 mRNA17484886|2733941
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SPC24 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SPC24 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of SPC24 mRNA19167446
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SPC24 mRNA24317228
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SPC24 mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of SPC24 mRNA27594783
D002117CalcitriolCalcitriol results in decreased expression of SPC24 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of SPC24 mRNA21592394
D004237DiuronDiuron metabolite results in decreased expression of SPC24 mRNA24172598
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SPC24 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SPC24 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SPC24 mRNA17351261
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of SPC24 mRNA24657277
D005839GentamicinsGentamicins results in increased expression of SPC24 mRNA22061828
D017313FenretinideFenretinide results in increased expression of SPC24 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of SPC24 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SPC24 mRNA24796395
D007840LatexLatex analog results in increased expression of SPC24 mRNA24768652
C045463leflunomideleflunomide results in decreased expression of SPC24 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of SPC24 mRNA24136188
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of SPC24 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of SPC24 mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SPC24 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SPC24 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SPC24 mRNA26011545
D009151Mustard GasMustard Gas results in decreased expression of SPC24 mRNA25102026
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SPC24 mRNA"29244179
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of SPC24 mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SPC24 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SPC24 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SPC24 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SPC24 mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of SPC24 mRNA22110744
D010100OxygenOxygen deficiency results in decreased expression of SPC24 mRNA26516004
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SPC24 mRNA25658374
D010126OzoneOzone results in increased expression of SPC24 mRNA25658374
C500026palbociclibpalbociclib results in decreased expression of SPC24 mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPC24 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of SPC24 mRNA19095052
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SPC24 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of SPC24 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SPC24 mRNA19482888
D048789PhytoestrogensPhytoestrogens results in increased expression of SPC24 mRNA18310284
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of SPC24 mRNA22484513
D010938Plant OilsPlant Oils results in decreased expression of SPC24 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SPC24 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SPC24 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SPC24 mRNA22698814
D011374ProgesteroneProgesterone results in decreased expression of SPC24 mRNA23018184
C005556propionaldehydepropionaldehyde results in decreased expression of SPC24 mRNA26079696
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SPC24 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SPC24 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of SPC24 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased expression of SPC24 mRNA17998272
D053260SootSoot results in increased expression of SPC24 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of SPC24 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SPC24 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPC24 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SPC24 mRNA28922406
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SPC24 mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of SPC24 mRNA23411599
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SPC24 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SPC24 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of SPC24 mRNA28973697
D014520UrethaneUrethane results in decreased expression of SPC24 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SPC24 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of SPC24 mRNA24535564
D015032ZincZinc deficiency results in increased expression of SPC24 mRNA22171008
C088658zoledronic acidzoledronic acid results in decreased expression of SPC24 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14738735  15961401  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-TAS-  
GO:0031262Ndc80 complex-IDA14699129  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29029446A potential prognostic biomarker SPC24 promotes tumorigenesis and metastasis in lung cancer. (2017 Sep 12)Zhou JOncotarget