Gene: ZNF582

147948
-
zinc finger protein 582
protein-coding
19q13.43
Ensembl:ENSG00000018869 MIM:615600 Vega:OTTHUMG00000181939 UniprotKB:Q96NG8
NG_050571.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.297e-1 (AD)  2.345e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
THUMPD10.793
PPHLN10.776
TMEM1810.775
PALB20.772
SMU10.771
DHX290.769
GORASP20.768
API50.768
PAIP10.768
EXOSC20.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.502
OR4F29-0.481
MTRNR2L10-0.335
MTRNR2L6-0.33
MTRNR2L9-0.309
KRTAP3-2-0.272
CSAG1-0.27
KLRB1-0.269
KCNJ15-0.263
MTRNR2L8-0.257

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of ZNF582 mRNA26690555
C015001arsenitearsenite results in decreased expression of ZNF582 mRNA23974009
C015001arsenitearsenite results in increased methylation of ZNF582 promoter23974009
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF582 mRNA27392435
D005472FluorouracilZNF582 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
D002955LeucovorinZNF582 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
C051890irinotecanZNF582 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF582 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ZNF582 mRNA27392435
D014635Valproic AcidValproic Acid results in decreased expression of ZNF582 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23907469DNA methylation of PAX1 as a biomarker for oral squamous cell carcinoma. (2014 Apr)Huang YKClin Oral Investig
27865370Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer. (2016 Nov)Cheng SJOral Oncol