Gene: NKX2-5

1482
CHNG5|CSX|CSX1|HLHS2|NKX2.5|NKX2E|NKX4-1|VSD3
NK2 homeobox 5
protein-coding
5q35.1
Ensembl:ENSG00000183072 MIM:600584 Vega:OTTHUMG00000130522 UniprotKB:P52952
NG_013340.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.318e-1 (AD)  7.077e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYBPC30.676
ANKRD10.611
CSRP30.606
TECRL0.595
XIRP10.587
TNNI30.561
MYH60.51
KLRB10.488
TREM10.486
SYNPO2L0.485

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SP9-0.296
RHEBL1-0.295
CDT1-0.294
PRKCZ-0.294
CORT-0.287
SYT3-0.283
NEUROD6-0.282
C16orf46-0.28
BCL11A-0.279
GJD4-0.274

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NKX2-5 protein"23284745
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of NKX2-5 mRNA12958071
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of NKX2-5 mRNA18544908
D000082AcetaminophenAcetaminophen results in decreased expression of NKX2-5 mRNA18544908
D020106AcrylamideAcrylamide results in decreased expression of NKX2-5 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NKX2-5 mRNA21298039
D006710HomocysteineHomocysteine results in decreased expression of NKX2-5 mRNA27203204
D006710HomocysteineHomocysteine results in decreased expression of NKX2-5 protein27203204
D006710HomocysteineParticulate Matter promotes the reaction [Homocysteine results in decreased expression of NKX2-5 protein]27203204
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NKX2-5 mRNA16483693
C015001arsenitearsenite results in increased methylation of NKX2-5 promoter23974009
D001205Ascorbic AcidAscorbic Acid results in increased expression of NKX2-5 mRNA12668514
D001374AzacitidineAzacitidine results in increased expression of NKX2-5 mRNA18557828
C547126AZM551248AZM551248 results in decreased expression of NKX2-5 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NKX2-5 mRNA22228805
C006780bisphenol Abisphenol A affects the methylation of NKX2-5 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of NKX2-5 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NKX2-5 mRNA26472689
C099555CD 437CD 437 results in decreased expression of NKX2-5 mRNA12958071
D003471CuprizoneCuprizone results in increased expression of NKX2-5 mRNA27523638
D003474CurcuminCurcumin results in decreased expression of NKX2-5 mRNA27237783
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NKX2-5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NKX2-5 mRNA19561079|2739243
D004041Dietary FatsDietary Fats results in increased expression of NKX2-5 mRNA25016146
D004317DoxorubicinDoxorubicin results in decreased expression of NKX2-5 mRNA11073966
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of NKX2-5 mRNA26476318
C089796hexabromocyclododecaneNKX2-5 protein affects the reaction [hexabromocyclododecane results in decreased expression of MIR1 mRNA]26476318
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of NKX2-5 mRNA23562911
C056599icariinicariin results in increased expression of NKX2-5 mRNA16490167
D007545Isoproterenol[Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA10710348
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NKX2-5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NKX2-5 mRNA24796395
C045463leflunomideleflunomide results in increased expression of NKX2-5 mRNA28988120
C028007nickel monoxidenickel monoxide results in decreased expression of NKX2-5 mRNA19167457
D052638Particulate MatterParticulate Matter promotes the reaction [Homocysteine results in decreased expression of NKX2-5 protein]27203204
D052638Particulate MatterParticulate Matter results in decreased expression of NKX2-5 mRNA27203204
D052638Particulate MatterParticulate Matter results in decreased expression of NKX2-5 protein27203204
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NKX2-5 mRNA23562911
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NKX2-5 mRNA23562911
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of NKX2-5 mRNA23941634
D010654Phenylbutyrates"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NKX2-5 protein"23284745
D010656Phenylephrine[Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA10710348
C006253pirinixic acidpirinixic acid results in increased expression of NKX2-5 mRNA17951219
D010936Plant ExtractsPlant Extracts results in decreased expression of NKX2-5 mRNA23557933
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of NKX2-5 mRNA21427059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NKX2-5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NKX2-5 mRNA20130022
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NKX2-5 protein20130022
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased localization of NKX2-5 protein26139165
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NKX2-5 mRNA24058054
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NKX2-5 mRNA27237783
D014212Tretinoin"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NKX2-5 protein"23284745
D014212TretinoinTretinoin results in decreased expression of NKX2-5 mRNA16423341
D014241TrichloroethyleneTrichloroethylene results in increased expression of NKX2-5 mRNA25847060
D014635Valproic AcidValproic Acid results in increased expression of NKX2-5 mRNA21427059|2723778
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NKX2-5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA22849347  26926761  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IMP15649947  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP15649947  
GO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding-IEA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA19578358  
GO:0003677DNA binding-IDA9858576  
GO:0003682chromatin binding-IDA16678093  
GO:0003700DNA-binding transcription factor activity-IDA9858576  10948187  11431700  
GO:0003700DNA-binding transcription factor activitycontributes_toIDA9312027  
GO:0003700DNA-binding transcription factor activity-IMP11431700  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0003712transcription coregulator activity-IEA-  
GO:0005515protein binding-IPI9312027  11431700  12499378  18579533  19797053  26926761  
GO:0008134transcription factor binding-IPI9858576  11431700  
GO:0010736serum response element binding-ISS8900537  
GO:0042803protein homodimerization activity-IEA-  
GO:0043565sequence-specific DNA binding-IDA10948187  
GO:0044212transcription regulatory region DNA binding-IDA19479054  
GO:0046982protein heterodimerization activity-ISS8900537  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP19479054  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS8900537  
GO:0001570vasculogenesis-ISS8900537  
GO:0001947heart looping-ISS8900537  
GO:0003007heart morphogenesis-ISS8900537  
GO:0003148outflow tract septum morphogenesis-IMP20807224  
GO:0003161cardiac conduction system development-IMP15109497  27207958  
GO:0003166bundle of His development-IEA-  
GO:0003168Purkinje myocyte differentiation-IEA-  
GO:0003211cardiac ventricle formation-IEA-  
GO:0003221right ventricular cardiac muscle tissue morphogenesis-IMP20807224  
GO:0003222ventricular trabecula myocardium morphogenesis-IEA-  
GO:0003278apoptotic process involved in heart morphogenesis-IEA-  
GO:0003285septum secundum development-IMP10587520  
GO:0003342proepicardium development-IEA-  
GO:0003350pulmonary myocardium development-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007512adult heart development-IMP9651244  
GO:0008284positive regulation of cell proliferation-ISS8900537  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IMP11889119  
GO:0010735positive regulation of transcription via serum response element binding-ISS8900537  
GO:0010765positive regulation of sodium ion transport-ISS8900537  
GO:0010832negative regulation of myotube differentiation-IMP15653675  
GO:0030097hemopoiesis-ISS8900537  
GO:0030154cell differentiation-ISS8900537  
GO:0030509BMP signaling pathway-IEA-  
GO:0030878thyroid gland development-IMP16418214  
GO:0035050embryonic heart tube development-ISS8900537  
GO:0043066negative regulation of apoptotic process-ISS8900537  
GO:0045214sarcomere organization-IEA-  
GO:0045666positive regulation of neuron differentiation-IMP15653675  
GO:0045823positive regulation of heart contraction-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS8900537  
GO:0045893positive regulation of transcription, DNA-templated-IDA11431700  
GO:0045893positive regulation of transcription, DNA-templated-ISS8900537  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10948187  19578358  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI10206974  16678093  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP11431700  15649947  18079734  19479054  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS8900537  
GO:0048536spleen development-IMP22560297  
GO:0048536spleen development-ISS8900537  
GO:0051891positive regulation of cardioblast differentiation-ISS8900537  
GO:0055005ventricular cardiac myofibril assembly-IEA-  
GO:0055007cardiac muscle cell differentiation-ISS8900537  
GO:0055008cardiac muscle tissue morphogenesis-IMP11889119  
GO:0055014atrial cardiac muscle cell development-ISS8900537  
GO:0055015ventricular cardiac muscle cell development-ISS8900537  
GO:0055117regulation of cardiac muscle contraction-ISS8900537  
GO:0060037pharyngeal system development-ISS8900537  
GO:0060038cardiac muscle cell proliferation-IEA-  
GO:0060043regulation of cardiac muscle cell proliferation-IEA-  
GO:0060048cardiac muscle contraction-IEA-  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:0060261positive regulation of transcription initiation from RNA polymerase II promoter-ISS8900537  
GO:0060347heart trabecula formation-IEA-  
GO:0060412ventricular septum morphogenesis-IMP10587520  20807224  
GO:0060413atrial septum morphogenesis-IMP9651244  10587520  
GO:0060928atrioventricular node cell development-IEA-  
GO:0060929atrioventricular node cell fate commitment-IEA-  
GO:0060971embryonic heart tube left/right pattern formation-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-ISS-  
GO:1903779regulation of cardiac conduction-ISS8900537  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA9858576  10948187  
GO:0005667transcription factor complex-IC9312027  
GO:0005737cytoplasm-IEA-  
GO:0032991protein-containing complex-IDA26926761  
GO:0032993protein-DNA complex-IDA22849347  
GO:0090575RNA polymerase II transcription factor complex-IDA9312027  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578768Physiological factorsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27237783Mainstream smoke and sidestream smoke affect the cardiac differentiation of mouse embryonic stem cells discriminately. (2016 May 16)Cheng WToxicology
26886562A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription. (2016 May)Song WHJ Hypertens
23467912Cardiomyocyte differentiation of perinatallyderived mesenchymal stem cells. (2013 May)Nartprayut KMol Med Rep