Gene: SYT6

148281
sytVI
synaptotagmin 6
protein-coding
1p13.2
Ensembl:ENSG00000134207 MIM:607718 Vega:OTTHUMG00000011755 UniprotKB:Q5T7P8
NG_050730.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.378e-1 (AD)  4.382e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs529989chr1:114135326 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GUCA1A0.697
DIRAS30.673
KL0.637
LRRC360.637
UPK1B0.636
TNFRSF190.636
GPRIN30.632
PDE10A0.623
CXADR0.619
DGKH0.608

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF182-0.361
RFX2-0.354
CDKN2C-0.348
SLC39A12-0.346
CLDN10-0.335
ACSS3-0.333
OTX1-0.333
NXNL1-0.328
PAX6-0.327
NWD1-0.32

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SYT6 mRNA"28712647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SYT6 mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SYT6 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SYT6 mRNA]17585979
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of SYT6 mRNA25607892
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYT6 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of SYT6 mRNA25607892
C015001arsenitearsenite results in increased methylation of SYT6 promoter23974009
D004958EstradiolEstradiol results in decreased expression of SYT6 mRNA19484750
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of SYT6 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of SYT6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SYT6 gene28505145
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of SYT6 mRNA25607892
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SYT6 mRNA18668222
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SYT6 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SYT6 mRNA]17585979
D003471CuprizoneCuprizone results in increased expression of SYT6 mRNA26577399
D004041Dietary FatsDietary Fats results in increased expression of SYT6 mRNA25016146
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of SYT6 mRNA25607892
D005419FlavonoidsFlavonoids results in increased expression of SYT6 mRNA18035473
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SYT6 mRNA17183730
D007657Ketone BodiesKetone Bodies results in decreased expression of SYT6 mRNA16807920
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SYT6 mRNA24810058
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of SYT6 mRNA25607892
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SYT6 mRNA26272509
D011441PropylthiouracilPropylthiouracil results in increased expression of SYT6 mRNA24780913
D043343Testosterone PropionateTestosterone Propionate results in increased expression of SYT6 mRNA15601916
D013849ThimerosalThimerosal results in decreased expression of SYT6 mRNA27188386
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SYT6 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of SYT6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SYT6 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IEA-  
GO:0005509calcium ion binding-IBA21873635  
GO:0005544calcium-dependent phospholipid binding-IBA21873635  
GO:0005544calcium-dependent phospholipid bindingNOTIDA7791877  
GO:0019905syntaxin binding-IBA21873635  
GO:0019905syntaxin binding-IDA7791877  
GO:0030276clathrin binding-IBA21873635  
GO:0030276clathrin binding-IDA7791877  
GO:0042803protein homodimerization activity-ISS-  
GO:0048306calcium-dependent protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006906vesicle fusion-IBA21873635  
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0017158regulation of calcium ion-dependent exocytosis-IBA21873635  
GO:0048791calcium ion-regulated exocytosis of neurotransmitter-IBA21873635  
GO:0060478acrosomal vesicle exocytosis-IMP11437455  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-ISS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-ISS-  
GO:0016021integral component of membrane-ISS-  
GO:0019898extrinsic component of membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0030672synaptic vesicle membrane-IEA-  
GO:0097038perinuclear endoplasmic reticulum-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal