Gene: CTBS

1486
CTB
chitobiase
protein-coding
1p22.3
Ensembl:ENSG00000117151 MIM:600873 Vega:OTTHUMG00000009922 UniprotKB:Q01459
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.036e-1 (AD)  6.958e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LIMS10.844
USP530.825
IRAK40.824
RPGR0.808
SERPINB10.805
PGGT1B0.803
RAP1B0.802
BNIP20.802
DERA0.801
CD1090.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.55
HNF1A-0.519
KCNG1-0.51
ELFN2-0.494
PIP5KL1-0.491
KCNIP3-0.486
RTN4R-0.486
ABCC12-0.479
OPRD1-0.478
CPLX3-0.477

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CTBS mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CTBS mRNA"19114083
C0155502,4',5-trichlorobiphenyl"2,4',5-trichlorobiphenyl results in decreased activity of CTBS protein"10190035
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTBS mRNA"27188386
C0804174-octylphenol4-octylphenol results in decreased activity of CTBS protein10051369
C1052604-tert-octylphenol4-tert-octylphenol results in decreased activity of CTBS protein10190035
C0293704-toluidine4-toluidine results in decreased expression of CTBS mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTBS mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CTBS mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CTBS mRNA24449571
C027423aroclor 1242aroclor 1242 results in decreased activity of CTBS protein10051369
D001280AtrazineAtrazine results in increased expression of CTBS mRNA22378314
C006780bisphenol Abisphenol A results in decreased methylation of CTBS promoter27312807
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of CTBS gene28505145
C006780bisphenol Abisphenol A results in increased expression of CTBS mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CTBS gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of CTBS mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CTBS mRNA17484886
C495817CC-8490CC-8490 results in increased expression of CTBS mRNA15604281
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CTBS gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of CTBS mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of CTBS mRNA27989131
C000944dicrotophosdicrotophos results in decreased expression of CTBS mRNA28302478
C007379diethyl phthalatediethyl phthalate results in decreased activity of CTBS protein10190035
D004054DiethylstilbestrolDiethylstilbestrol results in decreased activity of CTBS protein10051369
D004726EndosulfanEndosulfan results in decreased activity of CTBS protein10051369
C118739entinostatentinostat results in increased expression of CTBS mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CTBS mRNA17555576
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CTBS gene20938992
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of CTBS gene28505145
D005897GlafenineGlafenine results in decreased expression of CTBS mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CTBS mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CTBS mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CTBS mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CTBS gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CTBS mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CTBS mRNA23649840
C558013NSC 689534NSC 689534 results in increased expression of CTBS mRNA20971185
C018620oleoresinsoleoresins results in decreased expression of CTBS mRNA20008804
D010936Plant ExtractsPlant Extracts results in increased expression of CTBS mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of CTBS mRNA23608068
C010327salinomycinsalinomycin results in decreased expression of CTBS mRNA19682730
D012643SeleniumSelenium results in decreased expression of CTBS mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CTBS mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CTBS mRNA25351596
C017947sodium arsenitesodium arsenite affects the expression of CTBS mRNA29319823
D012999SomanSoman results in increased expression of CTBS mRNA19281266
D013629TamoxifenTamoxifen results in increased expression of CTBS mRNA15604281
D013629TamoxifenTamoxifen affects the expression of CTBS mRNA17555576
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CTBS mRNA25613284
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTBS mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CTBS mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of CTBS mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CTBS mRNA"26179874
D014520UrethaneUrethane results in decreased expression of CTBS mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CTBS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CTBS gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CTBS mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CTBS gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of CTBS mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004568chitinase activity-IBA21873635  
GO:0008061chitin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006032chitin catabolic process-IBA21873635  
GO:0009313oligosaccharide catabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005615extracellular space-HDA16502470  
GO:0005764lysosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14555188Disruption of oxygen-regulated responses underlies pathological changes in the placentas of women who smoke or who are passively exposed to smoke during pregnancy. (2003 Sep-Oct)Genbacev OReprod Toxicol