Gene: HJV

148738
HFE2|HFE2A|JH|RGMC
hemojuvelin BMP co-receptor
protein-coding
1q21.1
Ensembl:ENSG00000168509 MIM:608374 Vega:OTTHUMG00000013748 UniprotKB:Q6ZVN8
NG_011568.1
PubMed
0   ANCO-SNPs
OD|ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.783e-1 (AD)  6.882e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of HJV mRNA"25633564
C0524109-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of HJV mRNA"25633564
D000082AcetaminophenAcetaminophen results in decreased expression of HJV mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HJV protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HJV mRNA22100608|2715375
C015001arsenitearsenite results in increased methylation of HJV promoter23974009
D004958EstradiolEstradiol results in decreased expression of HJV mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of HJV mRNA20106945|2798913
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HJV mRNA26159488
C568376MT19c compoundMT19c compound results in decreased expression of HJV mRNA21781307
D010936Plant ExtractsPlant Extracts results in decreased expression of HJV mRNA23557933
C089730rosiglitazonerosiglitazone results in decreased expression of HJV mRNA25572481
C028632rutecarpinerutecarpine results in decreased expression of HJV mRNA25633564
C433985SU 9516SU 9516 results in decreased expression of HJV mRNA25633564
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HJV mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HJV mRNA20106945
C025643vinclozolinvinclozolin results in increased expression of HJV mRNA21126777
D015032ZincZinc deficiency results in increased expression of HJV mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI18326817  18335997  
GO:0005515protein binding-IPI18335997  18976966  19357398  22728873  
GO:0015026coreceptor activity-IBA21873635  
GO:0015026coreceptor activity-IDA16604073  
GO:0036122BMP binding-IPI18335997  
GO:0098821BMP receptor activitycontributes_toIDA16604073  
GO:1990459transferrin receptor binding-IPI22728873  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0006879cellular iron ion homeostasis-ISS-  
GO:0016540protein autoprocessing-IMP18335997  
GO:0030509BMP signaling pathway-IBA21873635  
GO:0030509BMP signaling pathway-IGI18326817  
GO:0030509BMP signaling pathway-IMP16604073  
GO:0030514negative regulation of BMP signaling pathway-IEA-  
GO:0032924activin receptor signaling pathway-IGI18326817  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16604073  18326817  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0055072iron ion homeostasis-IDA16075058  
GO:0055072iron ion homeostasis-IGI16075058  
GO:0071773cellular response to BMP stimulus-IMP16604073  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA17938254  25156943  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA16075058  17938254  
GO:0009986cell surface-IEA-  
GO:0031225anchored component of membrane-IEA-  
GO:0070724BMP receptor complex-IDA16604073  
GO:0098797plasma membrane protein complex-IDA18335997  
GO:1990712HFE-transferrin receptor complex-IDA22728873  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373752Netrin-1 signalingIEA
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26474245The role of genetic factors in patients with hepatocellular carcinoma and iron overload - a prospective series of 234 patients. (2016 May)Funakoshi NLiver Int