Gene: GLIS1

148979
-
GLIS family zinc finger 1
protein-coding
1p32.3
Ensembl:ENSG00000174332 MIM:610378 Vega:OTTHUMG00000008079 UniprotKB:Q8NBF1
NC_000001.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.335e-1 (AD)  1.232e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12075528chr1:53733811 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs797913chr1:53732889 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24741609chr1:54122060GLIS12.600e-23Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RCE10.795
TNFRSF250.789
ZGLP10.788
ZFHX20.783
CCDC1200.781
HIC20.777
RFX10.771
FGF170.767
QRICH20.755
TRIM110.753

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRCC1-0.478
RMDN1-0.41
ASB4-0.403
CCDC102B-0.402
SLC40A1-0.396
TMEM220-0.39
RGS22-0.386
SEPT10-0.386
CTSO-0.386
DPH6-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLIS1 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GLIS1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of GLIS1 mRNA"17331233
D001280AtrazineAtrazine results in increased expression of GLIS1 mRNA22378314
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GLIS1 gene20938992
D003520CyclophosphamideCyclophosphamide results in decreased expression of GLIS1 mRNA27281708
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GLIS1 gene20938992
D004397FonofosFonofos results in increased methylation of GLIS1 promoter22847954
D008713MethimazoleMethimazole results in increased expression of GLIS1 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GLIS1 gene20938992
D010278ParathionParathion results in increased methylation of GLIS1 promoter22847954
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GLIS1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of GLIS1 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of GLIS1 mRNA22504374
D012906SmokeSmoke results in increased expression of GLIS1 mRNA21095227
D012969Sodium FluorideSodium Fluoride results in increased expression of GLIS1 mRNA27862939
D012999SomanSoman results in increased expression of GLIS1 mRNA19281266
C012568terbufosterbufos results in increased methylation of GLIS1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLIS1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GLIS1 mRNA alternative form26582802
C009495titanium dioxidetitanium dioxide results in increased expression of GLIS1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of GLIS1 gene26756918
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of GLIS1 mRNA19042947
D014635Valproic AcidValproic Acid results in increased methylation of GLIS1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0006366transcription by RNA polymerase II-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal