Gene: CNIH3

149111
CNIH-3
cornichon family AMPA receptor auxiliary protein 3
protein-coding
1q42.12
Ensembl:ENSG00000143786 Vega:OTTHUMG00000037634 UniprotKB:Q8TBE1
NC_000001.11
PubMed|SNP Mapped
1   ANCO-SNPs
OD|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.489e-1 (AD)  4.696e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10799590chr1:224634780 (GRCh38.p7)G>Aopioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPNE40.932
CORO2A0.92
RASGRP10.918
CLSTN20.917
FAM102B0.913
CADPS0.911
DCLK10.909
CDK140.907
WDR70.906
DIRAS20.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.604
RAB13-0.6
REST-0.583
YES1-0.583
WWTR1-0.583
GNG12-0.569
ASB4-0.568
MAML2-0.564
CMTM3-0.558
CARD8-0.556

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of CNIH3 mRNA22230336
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CNIH3 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of CNIH3 mRNA19774075
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CNIH3 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CNIH3 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CNIH3 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of CNIH3 mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of CNIH3 mRNA25047013|2768578
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CNIH3 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of CNIH3 mRNA26079696
D016572CyclosporineCyclosporine results in increased expression of CNIH3 mRNA27989131
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CNIH3 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of CNIH3 mRNA25047013
D002945CisplatinCisplatin results in decreased expression of CNIH3 mRNA19561079
D002945CisplatinCisplatin results in increased expression of CNIH3 mRNA19561079
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CNIH3 mRNA26752646
D007854LeadLead affects the expression of CNIH3 mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CNIH3 mRNA"20188158
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of CNIH3 mRNA24888373
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CNIH3 mRNA26705709
D010634PhenobarbitalPhenobarbital results in increased expression of CNIH3 mRNA19084549
D010936Plant ExtractsPlant Extracts results in decreased expression of CNIH3 mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of CNIH3 mRNA24888373
D011192Potassium DichromatePotassium Dichromate results in increased expression of CNIH3 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CNIH3 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of CNIH3 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of CNIH3 mRNA17404688
C005556propionaldehydepropionaldehyde results in increased expression of CNIH3 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CNIH3 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CNIH3 mRNA24680724
D013853ThioacetamideThioacetamide results in decreased expression of CNIH3 mRNA23411599
D014635Valproic AcidValproic Acid affects the expression of CNIH3 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CNIH3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016247channel regulator activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0035249synaptic transmission, glutamatergic-IEA-  
GO:0042391regulation of membrane potential-IEA-  
GO:0048208COPII vesicle coating-TAS-  
GO:2000311regulation of AMPA receptor activity-IDA20805473  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0030054cell junction-IEA-  
GO:0032281AMPA glutamate receptor complex-ISS-  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-TAS-  
GO:0043198dendritic shaft-ISS-  
GO:0045211postsynaptic membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26239289Evidence of CNIH3 involvement in opioid dependence. (2016 May)Nelson ECMol Psychiatry