Gene: IL23R

149233
-
interleukin 23 receptor
protein-coding
1p31.3
Ensembl:ENSG00000162594 MIM:607562 Vega:OTTHUMG00000009092 UniprotKB:Q5VWK5
NG_011498.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.250e-1 (AD)  4.849e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XKR30.832
OR5AP20.771
OR2AP10.769
OR2B20.751
OR9G40.744
OR52K10.735
MMP200.732
TCHHL10.73
OR9K20.726
OR4K50.721

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C16orf95-0.287
C1orf53-0.265
C19orf73-0.253
TM7SF2-0.252
ASPDH-0.238
MMP15-0.227
CRH-0.224
FAM43B-0.222
THY1-0.22
KCNIP3-0.217

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A affects the expression of IL23R mRNA25181051
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of IL23R mRNA]17109745
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL23R mRNA26387944
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IL23R mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL23R mRNA25613284
C018091maduramicinmaduramicin results in increased expression of IL23R mRNA29128925
D015122MercaptopurineMercaptopurine results in increased expression of IL23R mRNA23358152
D008727MethotrexateMethotrexate results in decreased expression of IL23R mRNA24449571
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of IL23R mRNA27544571
C028473N-acetyl-4-benzoquinoneimineIL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D011192Potassium DichromatePotassium Dichromate results in increased expression of IL23R mRNA23608068
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL23R mRNA21570461
C479163tofacitinibtofacitinib inhibits the reaction [[IL6 protein co-treated with IL23A protein] results in increased expression of IL23R mRNA]21383241
D019287Zinc SulfateZinc Sulfate results in decreased expression of IL23R mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0005143interleukin-12 receptor bindingCONTRIBUTES_TOIBA21873635  
GO:0005143interleukin-12 receptor bindingcontributes_toIPI12023369  
GO:0005515protein binding-IPI12023369  25416956  
GO:0019955cytokine binding-IBA21873635  
GO:0042019interleukin-23 bindingCONTRIBUTES_TOIBA21873635  
GO:0042019interleukin-23 bindingcontributes_toIPI12023369  
GO:0042020interleukin-23 receptor activitycontributes_toIDA12023369  
GO ID GO Term Qualifier Evidence PubMed
GO:0001916positive regulation of T cell mediated cytotoxicity-ISS-  
GO:0002230positive regulation of defense response to virus by host-IDA12421946  
GO:0002230positive regulation of defense response to virus by host-ISS-  
GO:0002827positive regulation of T-helper 1 type immune response-IDA15114670  
GO:0002827positive regulation of T-helper 1 type immune response-ISS-  
GO:0006954inflammatory response-IEA-  
GO:0010536positive regulation of activation of Janus kinase activity-IC12023369  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032496response to lipopolysaccharide-IDA12023369  
GO:0032693negative regulation of interleukin-10 production-IMP16751425  
GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor production-IC20027291  
GO:0032729positive regulation of interferon-gamma production-IC20027291  
GO:0032729positive regulation of interferon-gamma production-IDA11114383  
GO:0032729positive regulation of interferon-gamma production-TAS19088061  
GO:0032735positive regulation of interleukin-12 production-IDA20027291  
GO:0032740positive regulation of interleukin-17 production-IC17888176  
GO:0032819positive regulation of natural killer cell proliferation-IC19088061  
GO:0034341response to interferon-gamma-IDA12023369  
GO:0038155interleukin-23-mediated signaling pathway-TAS-  
GO:0042102positive regulation of T cell proliferation-IC12023369  
GO:0042104positive regulation of activated T cell proliferation-IC11114383  
GO:0042509regulation of tyrosine phosphorylation of STAT protein-IC12023369  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IC12023369  19088061  
GO:0043382positive regulation of memory T cell differentiation-ISS-  
GO:0045672positive regulation of osteoclast differentiation-IC17888176  
GO:0050829defense response to Gram-negative bacterium-IC15114670  
GO:0051135positive regulation of NK T cell activation-IC19088061  
GO:2000318positive regulation of T-helper 17 type immune response-ISS-  
GO:2000330positive regulation of T-helper 17 cell lineage commitment-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
GO:0072536interleukin-23 receptor complex-IBA21873635  
GO:0072536interleukin-23 receptor complex-IDA12023369  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-9020933Interleukin-23 signalingIEA
R-HSA-9020933Interleukin-23 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20034760Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. (2010 May)Chandran VJ Autoimmun
28826742A comprehensive review and update on Crohn's disease. (2018 Feb)Gajendran MDis Mon
23288628Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct)Kurko JClin Rev Allergy Immunol
21206965IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes. (2011 Mar)Lauriola MInt J Mol Med
23468464Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment. (2014 Apr)Tillack CGut
23036591Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. (2012 Oct 4)Kazantseva MGArthritis Res Ther
22269043Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population. (2012 Jan 23)Kanaan ZMJ Negat Results Biomed
19953089Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease. (2010 May)van der Heide FAm J Gastroenterol
24989722Smoking behaviour modifies IL23r-associated disease risk in patients with Crohn's disease. (2015 Feb)Doecke JDJ Gastroenterol Hepatol
28400866Association of ERAP1, IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis. (2017)Ozen GOpen Rheumatol J