| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| DCSTAMP | 0.619 |
| KDELR3 | 0.597 |
| CRYGN | 0.595 |
| KERA | 0.575 |
| ANO7 | 0.543 |
| FCER2 | 0.539 |
| IGSF22 | 0.538 |
| GHRL | 0.537 |
| MAP1LC3C | 0.508 |
| OR1L3 | 0.504 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| RGS9BP | -0.323 |
| RXRG | -0.285 |
| NOG | -0.282 |
| C17orf50 | -0.261 |
| DBP | -0.26 |
| ABCD2 | -0.258 |
| RSPH10B | -0.255 |
| RAB41 | -0.251 |
| GABRG1 | -0.25 |
| HES6 | -0.249 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB06186 | Ipilimumab | BiotechDrug | 477202-00-9 | Approved | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C049325 | 1,2-dithiol-3-thione | "1,2-dithiol-3-thione results in increased expression of CTLA4 mRNA" | 19162173 |
| C009505 | 4,4'-diaminodiphenylmethane | "4,4'-diaminodiphenylmethane results in increased expression of CTLA4 mRNA" | 18648102 |
| D000638 | Amiodarone | Amiodarone results in increased expression of CTLA4 mRNA | 19774075 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of CTLA4 mRNA | 16483693 |
| D001151 | Arsenic | Arsenic affects the expression of CTLA4 protein | 24675094 |
| D001554 | Benzene | Benzene results in increased expression of CTLA4 mRNA | 19162166 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of CTLA4 mRNA | 22316170 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of CTLA4 mRNA | 22228805 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of CTLA4 mRNA | 25181051 |
| D003471 | Cuprizone | Cuprizone affects the expression of CTLA4 mRNA | 27523638 |
| C014347 | decitabine | decitabine results in increased expression of CTLA4 protein | 19545742 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in increased expression of CTLA4 mRNA | 21266533 |
| D004008 | Diclofenac | Diclofenac results in increased expression of CTLA4 protein | 26934552 |
| D004137 | Dinitrochlorobenzene | Dinitrochlorobenzene affects the expression of CTLA4 mRNA | 22302311 |
| D015025 | Zearalenone | Zearalenone results in increased expression of CTLA4 mRNA | 27757495 |
| D005419 | Flavonoids | Flavonoids results in increased expression of CTLA4 mRNA | 18035473 |
| C056933 | fumonisin B1 | fumonisin B1 results in increased expression of CTLA4 mRNA | 27757495 |
| C027478 | glucuronoxylomannan | glucuronoxylomannan results in increased expression of CTLA4 protein | 12864811 |
| C080043 | hexyl cinnamic aldehyde | hexyl cinnamic aldehyde affects the expression of CTLA4 mRNA | 22302311 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CTLA4 mRNA | 25613284 |
| C561695 | (+)-JQ1 compound | (+)-JQ1 compound results in decreased expression of CTLA4 mRNA | 23086925 |
| C028007 | nickel monoxide | nickel monoxide results in decreased expression of CTLA4 mRNA | 19167457 |
| C572573 | N-nitroso-tris-chloroethylurea | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of CTLA4 mRNA | 27935865 |
| C507134 | ON 01910 | ON 01910 results in increased expression of CTLA4 mRNA | 22351695 |
| C008776 | pelargonic acid | pelargonic acid affects the expression of CTLA4 mRNA | 22302311 |
| D009764 | o-Phthalaldehyde | o-Phthalaldehyde affects the expression of CTLA4 mRNA | 22302311 |
| C060836 | pioglitazone | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of CTLA4 mRNA | 27935865 |
| C006253 | pirinixic acid | NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of CTLA4 mRNA] | 17950772 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of CTLA4 mRNA | 17950772 |
| D019821 | Simvastatin | Simvastatin results in decreased expression of CTLA4 mRNA | 18453621 |
| D013739 | Testosterone | Testosterone results in increased expression of CTLA4 mRNA | 15788153 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of CTLA4 mRNA | 18684927 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of CTLA4 protein | 18684927 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CTLA4 mRNA | 25613284 |
| D014051 | Toluene 2,4-Diisocyanate | "Toluene 2,4-Diisocyanate results in increased expression of CTLA4 protein" | 27103660 |
| D014118 | Toxins, Biological | "Toxins, Biological affects the expression of CTLA4 mRNA" | 19682533 |
| C012589 | trichostatin A | trichostatin A results in increased expression of CTLA4 protein | 19545742 |
| C015559 | trimellitic anhydride | trimellitic anhydride affects the expression of CTLA4 mRNA | 22302311 |
| C015559 | trimellitic anhydride | trimellitic anhydride results in increased expression of CTLA4 mRNA | 19042947 |
| D014635 | Valproic Acid | Valproic Acid results in decreased methylation of CTLA4 gene | 29154799 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005515 | protein binding | - | IPI | 7807015 9398332 9813138 11279501 11279502 21982860 25241761 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0002250 | adaptive immune response | - | IEA | - |
| GO:0006955 | immune response | - | TAS | 3220103 |
| GO:0006974 | cellular response to DNA damage stimulus | - | IMP | 17875758 |
| GO:0030889 | negative regulation of B cell proliferation | - | IMP | 17875758 |
| GO:0031295 | T cell costimulation | - | TAS | - |
| GO:0042130 | negative regulation of T cell proliferation | - | IEA | - |
| GO:0043065 | positive regulation of apoptotic process | - | IMP | 17875758 |
| GO:0045589 | regulation of regulatory T cell differentiation | - | TAS | - |
| GO:0045590 | negative regulation of regulatory T cell differentiation | - | IDA | 18641304 |
| GO:0050777 | negative regulation of immune response | - | IEA | - |
| GO:0050853 | B cell receptor signaling pathway | - | IMP | 17875758 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005794 | Golgi apparatus | - | IDA | 15814706 |
| GO:0005886 | plasma membrane | - | TAS | - |
| GO:0005887 | integral component of plasma membrane | - | IMP | 28484017 |
| GO:0009897 | external side of plasma membrane | - | IDA | 18641304 |
| GO:0045334 | clathrin-coated endocytic vesicle | - | IDA | 15814706 |
| GO:0048471 | perinuclear region of cytoplasm | - | IDA | 15814706 |
| GO:0098636 | protein complex involved in cell adhesion | - | IDA | 7544393 |
| KEGG ID | KEGG Term |
|---|---|
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04660 | T cell receptor signaling pathway |
| hsa05320 | Autoimmune thyroid disease |
| hsa05323 | Rheumatoid arthritis |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-1280218 | Adaptive Immune System | TAS |
| R-HSA-168256 | Immune System | TAS |
| R-HSA-212436 | Generic Transcription Pathway | TAS |
| R-HSA-388841 | Costimulation by the CD28 family | TAS |
| R-HSA-389513 | CTLA4 inhibitory signaling | TAS |
| R-HSA-73857 | RNA Polymerase II Transcription | TAS |
| R-HSA-74160 | Gene expression (Transcription) | TAS |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | TAS |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 16868893 | Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. (2006 Jun) | Kurylowicz A | Exp Clin Endocrinol Diabetes |
| 20732370 | CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. (2010 Nov) | Liu Y | Hum Immunol |
| 20046016 | [Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?]. (2009 Dec) | Ohmura K | Nihon Rinsho Meneki Gakkai Kaishi |
| 25231450 | Thyroid autoimmunity. (2014) | Wiersinga WM | Endocr Dev |
| 23288628 | Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct) | Kurko J | Clin Rev Allergy Immunol |
| 17941906 | Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease. (2008 Mar) | Kisiel B | Clin Endocrinol (Oxf) |
| 18466513 | Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15. (2007) | Mei L | BMC Proc |
| 26267705 | Epigenetics and Primary Biliary Cirrhosis: a Comprehensive Review and Implications for Autoimmunity. (2016 Jun) | Xie YQ | Clin Rev Allergy Immunol |
| 19252239 | [Recent advances in the pathogenesis of rheumatoid arthritis]. (2009 Mar) | Kawabata K | Clin Calcium |
| 24289805 | rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population. (2014 Jan) | Szymanski K | Tissue Antigens |
| 15943829 | Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset. (2005 Jun) | Skorka A | Clin Endocrinol (Oxf) |
| 24390231 | Cytotoxic T lymphocyte antigen 4 (CTLA4) gene polymorphism with bladder cancer risk in North Indian population. (2014 Feb) | Jaiswal PK | Mol Biol Rep |
| 22968483 | Genotypes in relation to phenotypic appearance and exposure to environmental factors in Graves' hyperthyroidism. (2012 Dec) | Vos XG | Eur J Endocrinol |
| 17137217 | Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug) | Kokubo Y | Hypertens Res |
| 10351927 | Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis. (1999 Jun) | Israel-Assayag E | Am J Respir Crit Care Med |
| 29437869 | Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. (2018 Jun) | Ogino S | Gut |
| 24842313 | Tobacco smoking increases immune activation and impairs T-cell function in HIV infected patients on antiretrovirals: a cross-sectional pilot study. (2014) | Valiathan R | PLoS One |
| 21910726 | Role of increased CD8/CD28(null) T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease. (2011 Oct) | Hodge G | Clin Exp Immunol |
| 16279844 | Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. (2005 Oct) | Kurylowicz A | Thyroid |
| 20439292 | Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep) | van der Helm-van Mil AH | Ann Rheum Dis |