Gene: CTNS

1497
CTNS-LSB|PQLC4
cystinosin, lysosomal cystine transporter
protein-coding
17p13.2
Ensembl:ENSG00000040531 MIM:606272 Vega:OTTHUMG00000090693 UniprotKB:O60931
NG_012489.1
PubMed
0   ANCO-SNPs
ND
1   
2.049e-2 (AD)  5.086e-1 (ND)   (Frontal_Cortex)
2.361e-1 (AD)  6.475e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A20.79
ASCC20.789
ARAF0.781
RNPEPL10.778
SCAMP20.778
ABL10.776
DNM20.775
TMEM1040.774
TTLL40.769
CLN30.768

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.484
OR4F29-0.452
OR2T10-0.237
CRH-0.236
FREM3-0.221
SLC5A1-0.213
EGFL6-0.211
TRPC5-0.206
PTGFR-0.203
KCNH5-0.203

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00138CystineSmall Molecule56-89-3Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of CTNS mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CTNS mRNA"25614096
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of CTNS mRNA"23829299
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of CTNS mRNA25716159
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CTNS mRNA28522335
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of CTNS mRNA25412620
C044887beta-methylcholinebeta-methylcholine affects the expression of CTNS mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of CTNS mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of CTNS mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CTNS mRNA25979313
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CTNS mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of CTNS mRNA24386269
C029892cupric chloridecupric chloride results in decreased expression of CTNS mRNA24650576
D003471CuprizoneCuprizone results in increased expression of CTNS mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of CTNS mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CTNS mRNA20106945|2798913
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CTNS mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of CTNS gene22964155
C000944dicrotophosdicrotophos results in increased expression of CTNS mRNA28302478
D004147DioxinsDioxins affects the expression of CTNS mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CTNS mRNA22079256
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of CTNS mRNA25412620
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of CTNS mRNA19376150
D007213IndomethacinIndomethacin results in increased expression of CTNS mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CTNS mRNA25613284
C544151jinfukangjinfukang results in increased expression of CTNS mRNA27392435
C410337K 7174K 7174 results in increased expression of CTNS mRNA24086573
D007854LeadLead results in decreased expression of CTNS mRNA19921347
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CTNS mRNA26011545
C410127PCB 180PCB 180 results in increased expression of CTNS mRNA23829299
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CTNS mRNA23948077
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CTNS mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CTNS mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CTNS mRNA22079256
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CTNS mRNA21427059
D012834SilverSilver results in decreased expression of CTNS mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CTNS mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CTNS mRNA25613284
D014635Valproic AcidValproic Acid affects the expression of CTNS mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CTNS mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of CTNS gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CTNS mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CTNS gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015184L-cystine transmembrane transporter activity-IBA21873635  
GO:0015184L-cystine transmembrane transporter activity-IMP15128704  
GO:0015184L-cystine transmembrane transporter activity-NAS9537412  
GO:0015184L-cystine transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002088lens development in camera-type eye-IEA-  
GO:0006520cellular amino acid metabolic process-NAS9537412  
GO:0006749glutathione metabolic process-IMP15956064  
GO:0006811ion transport-TAS-  
GO:0007420brain development-IMP17471495  
GO:0007616long-term memory-IEA-  
GO:0007625grooming behavior-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0008542visual learning-IEA-  
GO:0010730negative regulation of hydrogen peroxide biosynthetic process-IEA-  
GO:0010918positive regulation of mitochondrial membrane potential-IEA-  
GO:0015811L-cystine transport-IBA21873635  
GO:0015811L-cystine transport-IMP7112129  15128704  
GO:0015811L-cystine transport-NAS9537412  
GO:0042438melanin biosynthetic process-IEA-  
GO:0046034ATP metabolic process-IMP16439594  
GO:0050890cognition-IMP17471495  
GO:0055085transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA11855931  12138135  15128704  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005765lysosomal membrane-IBA21873635  
GO:0005765lysosomal membrane-IDA11150305  
GO:0005765lysosomal membrane-NAS9537412  
GO:0005765lysosomal membrane-TAS-  
GO:0005769early endosomeNOTIDA11150305  
GO:0005770late endosome-IDA15128704  
GO:0005774vacuolar membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0042470melanosome-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045111intermediate filament cytoskeleton-IDA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-5223345Miscellaneous transport and binding eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res