Gene: BPIFB4

149954
C20orf186|LPLUNC4|RY2G5|dJ726C3.5
BPI fold containing family B member 4
protein-coding
20q11.21
Ensembl:ENSG00000186191 MIM:615718 Vega:OTTHUMG00000032235 UniprotKB:P59827
NC_000020.11
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.982e-1 (AD)  4.597e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs78109725chr20:33108365 (GRCh38.p7)C>Acocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VCY0.392
DUSP270.361
CLDN40.353
VN1R30.345
PNMA6A0.338
ST140.334
CCR30.334
OR52W10.333
PILRA0.332
ATP8B30.321

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LIFR-0.245
ITGB8-0.243
HVCN1-0.241
KAT2B-0.241
SASH1-0.237
GFRA1-0.232
PPARA-0.227
NUP62CL-0.227
KLF15-0.225
TMEM100-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of BPIFB4 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of BPIFB4 mRNA25181051
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of BPIFB4 gene23968726
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of BPIFB4 mRNA24534155
C031721naphthalenenaphthalene analog results in decreased expression of BPIFB4 mRNA24976557
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of BPIFB4 gene23968726
D011192Potassium DichromatePotassium Dichromate results in decreased expression of BPIFB4 mRNA23608068
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of BPIFB4 mRNA28934090
C057693troglitazonetroglitazone results in decreased expression of BPIFB4 mRNA28934090
D014635Valproic AcidValproic Acid results in increased methylation of BPIFB4 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008289lipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal